Drug General Information
Drug ID	D0H8PI
Former ID	DNC005584
Drug Name	6-(4-Hydroxy-phenyl)-naphthalen-1-ol
Synonyms	6-(4-hydroxyphenyl)-1-naphthol
Indication	Discovery agent		Investigative	[527584]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Estrogen receptor	Target Info	Inhibitor	[527584]
	Estradiol 17 beta-dehydrogenase 1	Target Info	Inhibitor	[529359]
	Estrogen receptor beta	Target Info	Inhibitor	[527584]
BioCyc Pathway	Superpathway of steroid hormone biosynthesis
	Estradiol biosynthesis I
KEGG Pathway	Estrogen signaling pathway
	Prolactin signaling pathway
	Thyroid hormone signaling pathway
	Endocrine and other factor-regulated calcium reabsorption
	Proteoglycans in cancerhsa00140:Steroid hormone biosynthesis
	Metabolic pathways
	Ovarian steroidogenesishsa04915:Estrogen signaling pathway
NetPath Pathway	FSH Signaling Pathway
	EGFR1 Signaling Pathway
	RANKL Signaling PathwayNetPath_25:FSH Signaling Pathway
PANTHER Pathway	Androgen/estrogene/progesterone biosynthesis
Pathway Interaction Database	Regulation of nuclear SMAD2/3 signaling
	Signaling events mediated by HDAC Class II
	Plasma membrane estrogen receptor signaling
	LKB1 signaling events
	Regulation of Telomerase
	ATF-2 transcription factor network
	AP-1 transcription factor network
	FOXM1 transcription factor network
	Validated nuclear estrogen receptor alpha network
	Signaling mediated by p38-alpha and p38-beta
	FOXA1 transcription factor networker_nongenomic_pathway:Plasma membrane estrogen receptor signaling
	Validated nuclear estrogen receptor beta network
PathWhiz Pathway	Androgen and Estrogen Metabolism
Reactome	Nuclear signaling by ERBB4
	Nuclear Receptor transcription pathwayR-HSA-2453902:The canonical retinoid cycle in rods (twilight vision)R-HSA-383280:Nuclear Receptor transcription pathway
WikiPathways	Estrogen signaling pathway
	Nuclear Receptors Meta-Pathway
	Estrogen Receptor Pathway
	Signaling by ERBB4
	JAK/STAT
	Integrated Pancreatic Cancer Pathway
	Leptin signaling pathway
	miR-targeted genes in muscle cell - TarBase
	Integrated Breast Cancer Pathway
	Nuclear ReceptorsWP496:Steroid Biosynthesis
	Metabolism of steroid hormones and vitamin D
	Prostate CancerWP706:SIDS Susceptibility Pathways
	Ovarian Infertility Genes
	Nuclear Receptors
References
Ref 527584	J Med Chem. 2005 Jun 16;48(12):3953-79.ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity.
Ref 527584	J Med Chem. 2005 Jun 16;48(12):3953-79.ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity.
Ref 529359	J Med Chem. 2008 Apr 10;51(7):2158-69. Epub 2008 Mar 7.Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.