Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0H1OL
|
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| Former ID |
DNC002557
|
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| Drug Name |
Guanosine
|
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| Drug Type |
Small molecular drug
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C10H13N5O5
|
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| InChI |
InChI=1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1
|
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| InChIKey |
NYHBQMYGNKIUIF-UUOKFMHZSA-N
|
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| CAS Number |
CAS 118-00-3
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
2780, 3677, 585265, 650442, 822708, 828520, 834086, 838453, 841595, 3133368, 7887938, 8026827, 8144918, 8154424, 10318628, 12075474, 14775401, 15914598, 16572157, 24715024, 25622152, 26512273, 26683878, 26710719, 26737546, 26754281, 29225747, 46392771, 46394142, 49830512, 49974991, 56413296, 57288125, 57323721, 74382935, 76715720, 77560081, 81044586, 81059141, 85164932, 85279369, 87570365, 88835475, 89649885, 90451714, 103510778, 103825631, 104313108, 117358482, 117529640
|
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| Target and Pathway | |||||
| Target(s) | DNA polymerase | Target Info | Inhibitor | [551393] | |
| HCMV DNA polymerase | Target Info | Inhibitor | [551393] | ||
| DNA polymerase (HSV-2) | Target Info | Inhibitor | [551393] | ||
| Purine nucleoside phosphorylase | Target Info | Inhibitor | [551393] | ||
| BioCyc Pathway | Arsenate detoxification I (glutaredoxin) | ||||
| Purine nucleotides degradation | |||||
| Urate biosynthesis/inosine 5'-phosphate degradation | |||||
| Purine deoxyribonucleosides degradation | |||||
| Purine ribonucleosides degradation to ribose-1-phosphate | |||||
| Guanosine nucleotides degradation | |||||
| Adenosine nucleotides degradation | |||||
| Superpathway of purine nucleotide salvage | |||||
| Adenine and adenosine salvage III | |||||
| Guanine and guanosine salvage | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| EGFR1 Signaling Pathway | |||||
| PathWhiz Pathway | Purine Metabolism | ||||
| Nicotinate and Nicotinamide Metabolism | |||||
| Reactome | Purine salvage | ||||
| Purine catabolism | |||||
| References | |||||
| Ref 467804 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4567). | ||||
| Ref 523731 | ClinicalTrials.gov (NCT01493570) Assessment of Exposure of BI 409306 in Cerebrospinal Fluid (CSF) Relative to Plasma as Well as to Evaluation of the Effect of Different Doses of BI 409306 on the cGMP(Cyclic Guanosine Monophosphate) Levels in CSF in Healthy Male Volunteers. U.S. National Institutes of Health. | ||||
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