Drug General Information
Drug ID
D0F3FC
Former ID
DIB007845
Drug Name
GSK-650394
Synonyms
SGK-1 inhibitor (prostate cancer), GlaxoSmithKline
Drug Type
Small molecular drug
Indication Prostate cancer [ICD9: 185; ICD10:C61] Investigative [542939]
Company
GlaxoSmithKline plc
Structure
Download
2D MOL

3D MOL

Formula
C25H22N2O2
InChI
InChI=1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29)
InChIKey
WVSBGSNVCDAMCF-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Serine/threonine-protein kinase Sgk1 Target Info Inhibitor [542938]
KEGG Pathway FoxO signaling pathway
PI3K-Akt signaling pathway
Aldosterone-regulated sodium reabsorption
NetPath Pathway IL5 Signaling Pathway
FSH Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database Insulin Pathway
Glucocorticoid receptor regulatory network
mTOR signaling pathway
FoxO family signaling
Class I PI3K signaling events
Reactome Stimuli-sensing channels
WikiPathways Insulin Signaling
Iron uptake and transport
FSH signaling pathway
References
Ref 542939(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8040).
Ref 542938(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8040).

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