Drug General Information
Drug ID
D0E3XG
Former ID
DIB003168
Drug Name
Zolasartan
Synonyms
GR-117289
Drug Type
Small molecular drug
Indication Hypotension [ICD9: 458, 796.3; ICD10:I95] Discontinued in Phase 2 [544984]
Company
Glaxo Wellcome plc
Structure
Download
2D MOL

3D MOL

Formula
C24H20BrClN6O3
Canonical SMILES
n1(c(c(nc1CCCC)Cl)C(=O)O)Cc1cc2c(c(oc2cc1)c1c(c2nnn[nH]<br />2)cccc1)Br
CAS Number
CAS 145781-32-4
PubChem Compound ID
Target and Pathway
Target(s) Type-1 angiotensin II receptor Target Info Agonist [531650]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Renin-angiotensin system
Renin secretion
Pathways in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Angiotensin II-stimulated signaling through G proteins and beta-arrestin
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Angiopoietin receptor Tie2-mediated signaling
PathWhiz Pathway Angiotensin Metabolism
Muscle/Heart Contraction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways ACE Inhibitor Pathway
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
Allograft Rejection
GPCR ligand binding
GPCR downstream signaling
References
Ref 544984Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001788)
Ref 531650Azilsartan: a newly approved angiotensin II receptor blocker. Cardiol Rev. 2011 Nov-Dec;19(6):300-4.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.