Drug Information
Drug General Information | |||||
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Drug ID |
D0DL2S
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Former ID |
DIB001191
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Drug Name |
MILFASARTAN
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Synonyms |
Tienartan; Arwin (Knoll); LR-B/081; Milfasartan < Prop INN >; 2-[4-Butyl-2-methyl-6-oxo-5-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1,6-dihydropyrimidin-1-ylmethyl]thiophene-3-carboxylic acid methyl ester; 4-Butyl-1-[3-(methoxycarbonyl)thien-2-ylmethyl]-2-methyl-5-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl-1,6-dihydropyrimidin-6-one
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Drug Type |
Small molecular drug
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Indication | Hypertension [ICD9: 401; ICD10:I10-I16] | Discontinued in Phase 2 | [545356] | ||
Structure |
Download2D MOL |
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Formula |
C30H30N6O3S
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Canonical SMILES |
CCCCC1=C(Cc2ccc(cc2)c3ccccc3c4nnn[nH]4)C(=O)N(Cc5sccc5C<br />(=O)OC)C(=N1)C
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InChI |
1S/C30H30N6O3S/c1-4-5-10-26-25(29(37)36(19(2)31-26)18-27-24(15-16-40-27)30(38)39-3)17-20-11-13-21(14-12-20)22-8-6-7-9-23(22)28-32-34-35-33-28/h6-9,11-16H,4-5,10,17-18H2,1-3H3,(H,32,33,34,35)
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InChIKey |
QVFVAKQHELFATN-UHFFFAOYSA-N
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CAS Number |
CAS 148564-47-0
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Type-1 angiotensin II receptor | Target Info | Antagonist | [532043], [551871] | |
NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
Pathway Interaction Database | Arf6 trafficking events | ||||
Arf6 signaling events | |||||
Angiopoietin receptor Tie2-mediated signaling | |||||
PathWhiz Pathway | Angiotensin Metabolism | ||||
Muscle/Heart Contraction | |||||
References |
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