Drug Information
Drug General Information | |||||
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Drug ID |
D0DA1E
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Former ID |
DIB018729
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Drug Name |
A-867744
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Synonyms |
A867744; A 867744
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [540601] | ||
Structure |
Download2D MOL |
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Formula |
C20H19ClN2O3S
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InChI |
InChI=1S/C20H19ClN2O3S/c1-3-20(24)18-12-19(14-4-6-15(21)7-5-14)23(13(18)2)16-8-10-17(11-9-16)27(22,25)26/h4-12H,3H2,1-2H3,(H2,22,25,26)
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InChIKey |
ABACVOXFUHDKNZ-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Neuronal acetylcholine receptor protein, alpha-7 chain | Target Info | Modulator (allosteric modulator) | [530093] | |
Acetylcholine receptor | Target Info | Blocker (channel blocker) | [530093] | ||
Neuronal acetylcholine receptor protein, beta-2 chain | Target Info | Blocker (channel blocker) | [530093] | ||
Reactome | Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsR-HSA-390648:Muscarinic acetylcholine receptors | ||||
Acetylcholine regulates insulin secretion | |||||
Highly sodium permeable acetylcholine nicotinic receptors | |||||
Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsR-HSA-629587:Highly sodium permeable acetylcholine nicotinic receptors | |||||
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | |||||
Highly calcium permeable nicotinic acetylcholine receptors | |||||
WikiPathways | SIDS Susceptibility Pathways | ||||
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellWP706:SIDS Susceptibility Pathways | |||||
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
Nicotine Activity on Dopaminergic Neurons | |||||
References | |||||
Ref 530093 | J Pharmacol Exp Ther. 2009 Jul;330(1):257-67. Epub 2009 Apr 23.In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile. |
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