Drug Information
Drug General Information | |||||
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Drug ID |
D0D5SQ
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Former ID |
DAP000524
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Drug Name |
Candesartan
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Synonyms |
Blopress; Candesartan [BAN]; CV 11974; CV11974; Amias (TN); Atacand (TN); Blopress (TN); CV-11974; Candesartan [USAN:INN]; KS-5003; Ratacand (TN); Candesartan (USAN/INN); Atacand, Blopress, Amias, Ratacand,Candesartan; 2-(ethyloxy)-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid; 2-Ethoxy-1-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-7-benzimidazolecarboxylic acid; 2-Ethoxy-3-[[4-[2-(1H-tetrazol-5-yl)phenyl]phenyl] methyl]-3H-benzoimidazole-4-carboxylic acid; 2-ethoxy-1-({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl)-1H-benzimidazole-7-carboxylic acid; 2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid; 2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4ethyl}-1H-benzimidazole-7-carboxylic acid; 2-ethoxy-3-[[4-[2-(1h-tetrazol-5-yl)phenyl]phenyl]methyl]-3h-benzoimidazole-4-carboxylic acid; 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid; 2-ethoxy-7-carboxy-1-(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methylbenzimidazole
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Drug Type |
Small molecular drug
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Therapeutic Class |
Antihypertensive Agents
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Company |
AstraZeneca
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Structure |
Download2D MOL |
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Formula |
C24H20N6O3
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InChI |
InChI=1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,31,32)(H,26,27,28,29)
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InChIKey |
HTQMVQVXFRQIKW-UHFFFAOYSA-N
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CAS Number |
CAS 139481-59-7
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PubChem Compound ID | |||||
PubChem Substance ID |
9671, 4688524, 7847588, 8151684, 11533318, 14930481, 29221703, 46508342, 48415685, 49830902, 49882690, 50112728, 53788093, 56311288, 56312082, 56312975, 56314032, 56314130, 57321365, 75340216, 80953765, 81080491, 85208995, 91611487, 92308938, 92712345, 93166508, 102979924, 103271913, 104098375, 104253227, 104300890, 117664419, 118049592, 124757352, 124893316, 125164156, 125340697, 126625640, 126656775, 126671130, 128111715, 131298518, 131299170, 134337816, 135023846, 135650050, 136340277, 136368010, 136375371
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ChEBI ID |
ChEBI:3347
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SuperDrug ATC ID |
C09CA06
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SuperDrug CAS ID |
cas=139481597
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Target and Pathway | |||||
Target(s) | Type-1 angiotensin II receptor | Target Info | Antagonist | [535067], [537549] | |
NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
Pathway Interaction Database | Arf6 trafficking events | ||||
Arf6 signaling events | |||||
Angiopoietin receptor Tie2-mediated signaling | |||||
PathWhiz Pathway | Angiotensin Metabolism | ||||
Muscle/Heart Contraction | |||||
References | |||||
Ref 536361 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. | ||||
Ref 541178 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 587). |
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