| Drug General Information |
| Drug ID |
D0C9ZE
|
| Former ID |
DNC003654
|
| Drug Name |
Benzoic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C14H17NO2
|
| Canonical SMILES |
C1CC2CC(C(C1)N2)OC(=O)C3=CC=CC=C3
|
| InChI |
1S/C14H17NO2/c16-14(10-5-2-1-3-6-10)17-13-9-11-7-4-8-12(13)15-11/h1-3,5-6,11-13,15H,4,7-9H2
|
| InChIKey |
AKLGENRCHBXEKW-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Muscarinic acetylcholine receptor M5 |
Target Info |
Inhibitor |
[1]
|
|---|
| Muscarinic acetylcholine receptor M3 |
Target Info |
Inhibitor |
[1]
|
| Muscarinic acetylcholine receptor M4 |
Target Info |
Inhibitor |
[1]
|
| Muscarinic acetylcholine receptor M1 |
Target Info |
Inhibitor |
[1]
|
| Muscarinic acetylcholine receptor M2 |
Target Info |
Inhibitor |
[1]
|
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KEGG Pathway
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Calcium signaling pathway
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Neuroactive ligand-receptor interaction
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Cholinergic synapse
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Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
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Regulation of actin cytoskeleton
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Insulin secretion
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Salivary secretion
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Gastric acid secretion
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Pancreatic secretionhsa04080:Neuroactive ligand-receptor interaction
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cAMP signaling pathway
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PI3K-Akt signaling pathway
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PANTHER Pathway
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Alzheimer disease-amyloid secretase pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Muscarinic acetylcholine receptor 2 and 4 signaling pathway
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PathWhiz Pathway
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Gastric Acid ProductionPW000564:Muscle/Heart Contraction
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Reactome
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Muscarinic acetylcholine receptors
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G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
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Acetylcholine regulates insulin secretion
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G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
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G alpha (i) signalling events
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WikiPathways
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Monoamine GPCRs
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Calcium Regulation in the Cardiac Cell
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Regulation of Actin Cytoskeleton
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GPCRs, Class A Rhodopsin-like
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCR ligand binding
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GPCR downstream signalingWP58:Monoamine GPCRs
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Integration of energy metabolism
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GPCR downstream signaling
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GPCRs, OtherWP58:Monoamine GPCRs
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Secretion of Hydrochloric Acid in Parietal Cells
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GPCR downstream signalingWP706:SIDS Susceptibility Pathways
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GPCRs, Other
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| References |
| REF 1 | J Med Chem. 2000 Jun 29;43(13):2514-22.6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors. |
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