Drug Information
Drug General Information | |||||
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Drug ID |
D0C3BA
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Former ID |
DIB008680
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Drug Name |
YM-358
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Synonyms |
2,7-Diethyl-5-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-5H-pyrazolo[1,5-b][1,2,4]triazole potassium salt monohydrate
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Drug Type |
Small molecular drug
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Indication | Hypertension [ICD9: 401; ICD10:I10-I16] | Phase 2 | [545253] | ||
Structure |
Download2D MOL |
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Formula |
C22H22N8
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Canonical SMILES |
CCc1cn(Cc2ccc(cc2)c3ccccc3c4nn[nH]n4)n5nc(CC)nc15
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InChI |
1S/C22H22N8/c1-3-16-14-29(30-22(16)23-20(4-2)26-30)13-15-9-11-17(12-10-15)18-7-5-6-8-19(18)21-24-27-28-25-21/h5-12,14H,3-4,13H2,1-2H3,(H,24,25,27,28)
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InChIKey |
LASWNZRBIPFGHP-UHFFFAOYSA-N
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CAS Number |
CAS 151406-07-4
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Type-1 angiotensin II receptor | Target Info | Antagonist | [525713], [551871] | |
NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
Pathway Interaction Database | Arf6 trafficking events | ||||
Arf6 signaling events | |||||
Angiopoietin receptor Tie2-mediated signaling | |||||
PathWhiz Pathway | Angiotensin Metabolism | ||||
Muscle/Heart Contraction | |||||
References | |||||
Ref 525713 | Effects of YM358, an angiotensin II type 1 (AT1) receptor antagonist, and enalapril on blood pressure and vasoconstriction in two renal hypertension models. Biol Pharm Bull. 2000 Feb;23(2):174-81. | ||||
Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 |
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