Drug Information

Drug General Information
Drug ID
D0AU0M
Former ID
DNC010454
Drug Name
P-Coumaric Acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541106]
Structure
Download
2D MOL

3D MOL
Formula
C9H8O3
InChI
InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/b6-3+
InChIKey
NGSWKAQJJWESNS-ZZXKWVIFSA-N
PubChem Compound ID
637542
PubChem Substance ID
4069, 107565, 515621, 588041, 591088, 611431, 3133439, 8034050, 8704395, 10523171, 10524290, 10534360, 15321780, 17425116, 17425120, 22394957, 22394960, 24893127, 29203982, 43759852, 46508796, 47193719, 49834951, 49955172, 49955173, 53789034, 56310611, 57407628, 74816815, 81040487, 87565521, 88508920, 91234628, 92249962, 92297678, 92709780, 103139453, 103263375, 104223119, 104669108, 111677728, 111677750, 111678048, 113526800, 117544886, 117605431, 118052865, 124595258, 124758176, 124758276
Target and Pathway
Target(s) Carbonic anhydrase XII Target Info Inhibitor [530751]
Carbonic anhydrase II Target Info Inhibitor [530751]
Carbonic anhydrase XIV Target Info Inhibitor [530751]
Carbonic anhydrase IX Target Info Inhibitor [530751]
Carbonic anhydrase VI Target Info Inhibitor [530751]
Carbonic anhydrase I Target Info Inhibitor [530751]
Carbonic anhydrase IV Target Info Inhibitor [530751]
Carbonic anhydrase Target Info Inhibitor [530751]
KEGG Pathway Nitrogen metabolismhsa00910:Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretionhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
NetPath Pathway TGF_beta_Receptor Signaling PathwayNetPath_16:IL4 Signaling Pathway
EGFR1 Signaling Pathway
Pathway Interaction Database HIF-1-alpha transcription factor networkcmyb_pathway:C-MYB transcription factor network
PathWhiz Pathway Gastric Acid Production
Reactome Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon DioxideWP2877:Vitamin D Receptor Pathway
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 541106(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5787).
Ref 530751Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.

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