Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0A8XY
|
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| Former ID |
DIB013537
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| Drug Name |
Altropane
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| Synonyms |
Carbon-11-Altropane; Iodine-123-Altropane; 11C-Altropane; 123I-Altropane
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| Drug Type |
Small molecular drug
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| Indication | Attention deficit hyperactivity disorder [ICD9: 314; ICD10:F90] | Approved | [1] | ||
| Company |
Harvard University
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| Structure |
|
Download2D MOL |
|||
| Formula |
C18H21FINO2
|
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| Canonical SMILES |
C1(C2N(C(CC1c1ccc(cc1)F)CC2)CC=C)C(=O)OC
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| CAS Number |
CAS 127648-29-7
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Sodium-dependent dopamine transporter | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Dopaminergic synapse | ||||
| Parkinson's disease | |||||
| Cocaine addiction | |||||
| Amphetamine addiction | |||||
| Alcoholism | |||||
| PANTHER Pathway | Adrenaline and noradrenaline biosynthesis | ||||
| Parkinson disease | |||||
| Dopamine receptor mediated signaling pathway | |||||
| Pathway Interaction Database | Alpha-synuclein signaling | ||||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | ||||
| WikiPathways | Monoamine Transport | ||||
| NRF2 pathway | |||||
| Dopaminergic Neurogenesis | |||||
| Parkinsons Disease Pathway | |||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | |||||
| Neurotransmitter Clearance In The Synaptic Cleft | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT00596908) 123I-ALTROPANE Reference Image Acquisition in Subjects With Diagnostically Uncertain Tremor. U.S. National Institutes of Health. | ||||
| REF 2 | Rapid detection of Parkinson's disease by SPECT with altropane: a selective ligand for dopamine transporters. Synapse. 1998 Jun;29(2):128-41. | ||||
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