Drug Information

Drug General Information
Drug ID
D09UND
Former ID
DNC008413
Drug Name
12,17-dehydroxyriccardin C
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529375]
Structure
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2D MOL

3D MOL
Formula
C28H24O2
Canonical SMILES
C1CC2=CC(=C(C=C2)O)OC3=CC=C(CCC4=CC=CC=C4C5=CC=C1C=C5)C<br />=C3
InChI
1S/C28H24O2/c29-27-18-12-22-6-5-20-8-14-24(15-9-20)26-4-2-1-3-23(26)13-7-21-10-16-25(17-11-21)30-28(27)19-22/h1-4,8-12,14-19,29H,5-7,13H2
InChIKey
CTGIBRGBEVEPID-UHFFFAOYSA-N
PubChem Compound ID
24860514
Target and Pathway
Target(s) Oxysterols receptor LXR-alpha Target Info Inhibitor [529375]
Oxysterols receptor LXR-beta Target Info Inhibitor [529375]
KEGG Pathway PPAR signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis C
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
Reactome Nuclear Receptor transcription pathway
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Liver X Receptor Pathway
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Nuclear ReceptorsWP1982:SREBP signalling
Nuclear Receptors
References
Ref 529375Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development.
Ref 529375Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development.

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