Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09EXD
|
||||
| Former ID |
DAP000382
|
||||
| Drug Name |
Rituximab
|
||||
| Synonyms |
MAbThera (TN); Rituxan (TN)
|
||||
| Drug Type |
Antibody
|
||||
| Indication | Non-hodgkin's lymphoma [ICD10:C85] | Approved | [1], [2] | ||
| Hematologic malignancies [ICD9: 200-209; ICD10:C81-C86] | Phase 1 | [1], [2] | |||
| Therapeutic Class |
Anticancer Agents
|
||||
| Company |
Roche
|
||||
| Formula |
C6416H9874N1688O1987S44
|
||||
| CAS Number |
CAS 174722-31-7
|
||||
| PubChem Substance ID | |||||
| SuperDrug ATC ID |
L01XC02
|
||||
| Drug Resistance Mutation (DRM) | |||||
| DRM | DRM Info | ||||
| Target and Pathway | |||||
| Target(s) | B-lymphocyte antigen CD20 | Target Info | [3], [4] | ||
| KEGG Pathway | Hematopoietic cell lineage | ||||
| References | |||||
| REF 1 | Disease-modifying agents for multiple sclerosis: recent advances and future prospects. Drugs. 2008;68(17):2445-68. doi: 10.2165/0003495-200868170-00004. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6780). | ||||
| REF 3 | Knockouts model the 100 best-selling drugs--will they model the next 100? Nat Rev Drug Discov. 2003 Jan;2(1):38-51. | ||||
| REF 4 | Contribution of radioimmunotherapy to the treatment of lymphoma. Ann Pharm Fr. 2008 Nov-Dec;66(5-6):300-8. Epub 2008 Nov 8. | ||||
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