Drug Information

Drug General Information
Drug ID
D09DAC
Former ID
DNC004752
Drug Name
Des-AA1,2,4,12,13-[D-Trp8]SRIF
Indication Discovery agent Investigative [527385]
Structure
Download
2D MOL

3D MOL
Formula
C58H72N12O12S2
Canonical SMILES
CC(C1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O<br />)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=<br />C4)CC5=CC=CC=C5)CC(=O)N)N)C(=O)O)CC6=CC=CC=C6)O
InChI
1S/C58H72N12O12S2/c1-33(71)49-57(80)68-44(27-36-19-9-4-10-20-36)54(77)69-47(58(81)82)32-84-83-31-39(60)50(73)64-46(29-48(61)72)56(79)66-42(25-34-15-5-2-6-16-34)52(75)65-43(26-35-17-7-3-8-18-35)53(76)67-45(28-37-30-62-40-22-12-11-21-38(37)40)55(78)63-41(51(74)70-49)23-13-14-24-59/h2-12,15-22,30,33,39,41-47,49,62,71H,13-14,23-29,31-32,59-60H2,1H3,(H2,61,72)(H,63,78)(H,64,73)(H,65,75)(H,66,79)(H,67,76)(H,68,80)(H,69,77)(H,70,74)(H,81,82)/t33-,39-,41+,42-,43+,44+,45+,46+,47+,49-/m1/s1
InChIKey
LAZNVYHNZZBPSL-ZXQPUDBWSA-N
PubChem Compound ID
44388046
Target and Pathway
Target(s) Somatostatin receptor type 3 Target Info Inhibitor [527385]
Somatostatin receptor type 5 Target Info Inhibitor [527385]
Somatostatin receptor type 2 Target Info Inhibitor [527385]
Somatostatin receptor type 4 Target Info Inhibitor [527385]
Somatostatin receptor 1 Target Info Inhibitor [527385]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04024:cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretionhsa04080:Neuroactive ligand-receptor interactionhsa04024:cAMP signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 527385J Med Chem. 2005 Jan 27;48(2):515-22.Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides.
Ref 527385J Med Chem. 2005 Jan 27;48(2):515-22.Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides.

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