Drug General Information
Drug ID
D09CVV
Former ID
DNC013482
Drug Name
NORSTEPHALAGINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551362]
Structure
Download
2D MOL

3D MOL

Formula
C18H17NO3
Canonical SMILES
COC1=C2CCNC3C2=C(C4=CC=CC=C4C3)C5=C1OCO5
InChI
1S/C18H17NO3/c1-20-16-12-6-7-19-13-8-10-4-2-3-5-11(10)15(14(12)13)17-18(16)22-9-21-17/h2-5,13,19H,6-9H2,1H3/t13-/m1/s1
InChIKey
TYZKUSBTFHNPMV-CYBMUJFWSA-N
PubChem Compound ID
Target and Pathway
Target(s) Dopamine D1 receptor Target Info Inhibitor [528616]
Sodium-dependent dopamine transporter Target Info Inhibitor [551362]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholismhsa04728:Dopaminergic synapse
Alcoholism
PANTHER Pathway Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (s) signalling eventsR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signalingWP727:Monoamine Transport
NRF2 pathway
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 551362Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84.
Ref 528616J Med Chem. 2007 Jan 25;50(2):171-81.Advances in development of dopaminergic aporphinoids.
Ref 551362Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84.

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