| Drug General Information |
| Drug ID |
D08XPW
|
| Former ID |
DNC005608
|
| Drug Name |
CYTISINE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C11H14N2O
|
| InChI |
InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8-,9+/m0/s1
|
| InChIKey |
ANJTVLIZGCUXLD-DTWKUNHWSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
589961, 8157380, 10321241, 11112361, 11113087, 11114058, 15899404, 16325148, 22390246, 26752181, 29204005, 29228756, 47434815, 47434816, 48179676, 48253910, 49698590, 49833166, 49960142, 50124228, 56463106, 57326061, 74570465, 76715582, 85148349, 85787849, 88528961, 103654654, 104032478, 104121483, 104253548, 104322739, 104825241, 117673734, 118867704, 121363225, 124757690, 124801290, 124882289, 124882290, 124882291, 125164494, 126594023, 126688798, 134342813, 134975346, 135544049, 136187309, 137248536, 151972521
|
| Target and Pathway |
| Target(s) |
Neuronal acetylcholinereceptor subunit alpha-2 |
Target Info |
Inhibitor |
[2]
|
|---|
| Neuronal acetylcholine receptor protein, alpha-4 chain |
Target Info |
Inhibitor |
[3]
|
| Neuronal acetylcholine receptor protein, beta-4 chain |
Target Info |
Inhibitor |
[4]
|
| Neuronal acetylcholine receptor protein, beta-2 chain |
Target Info |
Inhibitor |
[3]
|
| Neuronal acetylcholine receptor protein, alpha-7 chain |
Target Info |
Inhibitor |
[5]
|
|
KEGG Pathway
|
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
|
|
Cholinergic synapse
|
|
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
|
|
Cholinergic synapsehsa04080:Neuroactive ligand-receptor interaction
|
|
Nicotine addictionhsa04020:Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Nicotine addiction
|
|
Chemical carcinogenesis
|
|
PANTHER Pathway
|
Nicotinic acetylcholine receptor signaling pathwayP00044:Nicotinic acetylcholine receptor signaling pathway
|
|
Nicotine pharmacodynamics pathwayP00044:Nicotinic acetylcholine receptor signaling pathway
|
|
Nicotine pharmacodynamics pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
|
Nicotinic acetylcholine receptor signaling pathway
|
|
Reactome
|
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
|
|
Highly calcium permeable nicotinic acetylcholine receptorsR-HSA-629587:Highly sodium permeable acetylcholine nicotinic receptors
|
|
Highly calcium permeable nicotinic acetylcholine receptorsR-HSA-629594:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
|
|
WikiPathways
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellWP706:SIDS Susceptibility Pathways
|
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
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Nicotine Activity on Dopaminergic NeuronsWP706:SIDS Susceptibility Pathways
|
|
Nicotine Activity on Chromaffin CellsWP706:SIDS Susceptibility Pathways
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5347). |
|---|
| REF 2 | J Med Chem. 2006 May 4;49(9):2673-6.Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity. |
|---|
| REF 3 | Bioorg Med Chem Lett. 2006 Nov 1;16(21):5493-7. Epub 2006 Aug 28.Epibatidine isomers and analogues: structure-activity relationships. |
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| REF 4 | Bioorg Med Chem Lett. 2008 Apr 1;18(7):2316-9. Epub 2008 Mar 6.Deconstructing cytisine: The syntheses of (+/-)-cyfusine and (+/-)-cyclopropylcyfusine, fused ring analogs of cytisine. |
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| REF 5 | Bioorg Med Chem Lett. 2005 Nov 15;15(22):4889-97.3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation. |
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