Drug Information

Drug General Information
Drug ID
D08URT
Former ID
DIB018535
Drug Name
24(S)-hydroxycholesterol
Synonyms
24s-OHC
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539795]
Structure
Download
2D MOL
Formula
C27H46O2
InChI
InChI=1S/C27H46O2/c1-17(2)25(29)11-6-18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20+,21+,22-,23+,24+,25+,26+,27-/m1/s1
InChIKey
IOWMKBFJCNLRTC-XWXSNNQWSA-N
PubChem Compound ID
121948
PubChem Substance ID
7846926, 7850678, 10239882, 14854897, 16101083, 22396036, 29302437, 49688255, 51004216, 53788341, 57339865, 57394003, 87550981, 103428735, 103819206, 104414673, 126524038, 135076031, 135651391, 136069447, 137136433, 139022586, 163027990, 179316850, 198964314, 226557621
Target and Pathway
Target(s) Oxysterols receptor LXR-beta Target Info Agonist [534311]
Oxysterols receptor LXR-alpha Target Info Agonist [534311]
KEGG Pathway PPAR signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis C
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
Reactome Nuclear Receptor transcription pathway
WikiPathways SREBP signalling
Nuclear ReceptorsWP299:Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Liver X Receptor Pathway
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Nuclear Receptors
References
Ref 539795(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2750).
Ref 534311Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem. 1997 Feb 7;272(6):3137-40.

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