Drug Information

Drug General Information
Drug ID
D08QXD
Former ID
DIB020177
Drug Name
L-783483
Synonyms
F3MethylAA
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539750]
Structure
Download
2D MOL
Formula
C22H21ClF3NO4S
InChI
InChI=1S/C22H21ClF3NO4S/c1-2-4-14-17(7-6-15-20(14)31-27-21(15)22(24,25)26)30-9-3-10-32-18-8-5-13(11-16(18)23)12-19(28)29/h5-8,11H,2-4,9-10,12H2,1H3,(H,28,29)
InChIKey
TZBRFAASYWFUGK-UHFFFAOYSA-N
PubChem Compound ID
9935197
PubChem Substance ID
14908287, 24209543, 80647381, 93578097, 103191560, 104018161, 129334623, 135650496, 140304310, 228966490
Target and Pathway
Target(s) mRNA of PPAR-gamma Target Info Agonist [525425]
Oxysterols receptor LXR-alpha Target Info Agonist [535486]
Peroxisomeproliferator activated receptor delta Target Info Agonist [525425]
Oxysterols receptor LXR-beta Target Info Agonist [535486]
KEGG Pathway PPAR signaling pathway
AMPK signaling pathway
Osteoclast differentiation
Huntington's disease
Pathways in cancer
Transcriptional misregulation in cancer
Thyroid cancerhsa03320:PPAR signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis Chsa03320:PPAR signaling pathway
Wnt signaling pathway
Acute myeloid leukemia
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway CCKR signaling map STP00057:Wnt signaling pathway
Pathway Interaction Database Noncanonical Wnt signaling pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by HDAC Class I
RXR and RAR heterodimerization with other nuclear receptor
Regulation of retinoblastoma proteinrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptorps1pathway:Presenilin action in Notch and Wnt signaling
RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
Reactome PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathwayR-HSA-200425:Import of palmitoyl-CoA into the mitochondrial matrix
Regulation of pyruvate dehydrogenase (PDH) complex
Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
WikiPathways Wnt Signaling Pathway Netpath
Nuclear Receptors in Lipid Metabolism and Toxicity
Differentiation of white and brown adipocyte
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional Regulation of White Adipocyte Differentiation
Adipogenesis
SREBP signalling
Nuclear ReceptorsWP299:Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Liver X Receptor Pathway
SREBF and miR33 in cholesterol and lipid homeostasis
Nuclear ReceptorsWP399:Wnt Signaling Pathway and Pluripotency
NRF2 pathway
Vitamin D Receptor Pathway
Ectoderm Differentiation
Nuclear ReceptorsWP1982:SREBP signalling
Nuclear Receptors
References
Ref 539750(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2688).
Ref 525425Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects. J Biol Chem. 1999 Mar 5;274(10):6718-25.
Ref 535486A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a). Endocrinology. 2002 Jul;143(7):2548-58.

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