Drug Information

Drug General Information
Drug ID
D08ELY
Former ID
DNC003613
Drug Name
3-Benzenesulfonyl-heptanoic acid hydroxyamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [525813]
Structure
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2D MOL

3D MOL
Formula
C13H19NO4S
Canonical SMILES
CCCCC(CC(=O)NO)S(=O)(=O)C1=CC=CC=C1
InChI
1S/C13H19NO4S/c1-2-3-7-12(10-13(15)14-16)19(17,18)11-8-5-4-6-9-11/h4-6,8-9,12,16H,2-3,7,10H2,1H3,(H,14,15)
InChIKey
TUUMURVUDGZZQZ-UHFFFAOYSA-N
PubChem Compound ID
9838786
Target and Pathway
Target(s) Interstitial collagenase Target Info Inhibitor [525813]
Collagenase 3 Target Info Inhibitor [525813]
MMP-12 Target Info Inhibitor [525813]
Matrilysin Target Info Inhibitor [525813]
KEGG Pathway PPAR signaling pathway
Pathways in cancer
Bladder cancer
Rheumatoid arthritishsa04310:Wnt signaling pathway
NetPath Pathway IL1 Signaling Pathway
EGFR1 Signaling Pathway
TWEAK Signaling Pathway
Wnt Signaling PathwayNetPath_13:IL1 Signaling PathwayNetPath_13:IL1 Signaling Pathway
IL5 Signaling PathwayNetPath_8:Wnt Signaling Pathway
PANTHER Pathway Alzheimer disease-presenilin pathway
Plasminogen activating cascadeP00004:Alzheimer disease-presenilin pathway
Wnt signaling pathway
CCKR signaling map ST
Pathway Interaction Database Endothelins
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Glucocorticoid receptor regulatory network
AP-1 transcription factor network
Syndecan-1-mediated signaling eventsupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalingupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalingajdiss_2pathway:Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Syndecan-1-mediated signaling events
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Basigin interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)R-HSA-1442490:Collagen degradation
Assembly of collagen fibrils and other multimeric structuresR-HSA-1442490:Collagen degradation
Degradation of the extracellular matrixR-HSA-1442490:Collagen degradation
Assembly of collagen fibrils and other multimeric structures
WikiPathways TGF beta Signaling Pathway
Bladder Cancer
Activation of Matrix Metalloproteinases
Degradation of collagen
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Oncostatin M Signaling Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Cell surface interactions at the vascular wall
Matrix MetalloproteinasesWP474:Endochondral Ossification
AGE/RAGE pathway
Matrix MetalloproteinasesWP366:TGF beta Signaling Pathway
Matrix MetalloproteinasesWP399:Wnt Signaling Pathway and Pluripotency
Matrix Metalloproteinases
References
Ref 525813J Med Chem. 2000 Jun 15;43(12):2324-31.Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents.
Ref 525813J Med Chem. 2000 Jun 15;43(12):2324-31.Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents.

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