Drug Information
Drug General Information | |||||
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Drug ID |
D08BZR
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Former ID |
DNC004887
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Drug Name |
4-(2-Amino-ethyl)-benzenesulfonamide
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [527645] | ||
Structure |
Download2D MOL |
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Formula |
C8H12N2O2S
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Canonical SMILES |
C1=CC(=CC=C1CCN)S(=O)(=O)N
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InChI |
1S/C8H12N2O2S/c9-6-5-7-1-3-8(4-2-7)13(10,11)12/h1-4H,5-6,9H2,(H2,10,11,12)
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InChIKey |
FXNSVEQMUYPYJS-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Carbonic anhydrase I | Target Info | Inhibitor | [527645] | |
Carbonic anhydrase IV | Target Info | Inhibitor | [527415] | ||
Carbonic anhydrase | Target Info | Inhibitor | [527408] | ||
Carbonic anhydrase II | Target Info | Inhibitor | [527645] | ||
Carbonic anhydrase XII | Target Info | Inhibitor | [527407] | ||
Carbonic anhydrase IX | Target Info | Inhibitor | [527645] | ||
Carbonic anhydrase XIV | Target Info | Inhibitor | [527654] | ||
KEGG Pathway | Nitrogen metabolismhsa00910:Nitrogen metabolism | ||||
Proximal tubule bicarbonate reclamationhsa00910:Nitrogen metabolism | |||||
Proximal tubule bicarbonate reclamation | |||||
Collecting duct acid secretion | |||||
Gastric acid secretion | |||||
Pancreatic secretion | |||||
Bile secretionhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism | |||||
Pathway Interaction Database | C-MYB transcription factor networkhif1_tfpathway:HIF-1-alpha transcription factor network | ||||
PathWhiz Pathway | Gastric Acid Production | ||||
Reactome | Erythrocytes take up carbon dioxide and release oxygen | ||||
Erythrocytes take up oxygen and release carbon dioxide | |||||
Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen | |||||
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor | |||||
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxide | |||||
WikiPathways | Reversible Hydration of Carbon Dioxide | ||||
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | |||||
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide | |||||
miR-targeted genes in muscle cell - TarBase | |||||
miR-targeted genes in leukocytes - TarBase | |||||
miR-targeted genes in epithelium - TarBaseWP2877:Vitamin D Receptor Pathway | |||||
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide | |||||
References | |||||
Ref 527407 | Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9.Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?. | ||||
Ref 527408 | Bioorg Med Chem Lett. 2005 Feb 15;15(4):971-6.Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides. | ||||
Ref 527415 | Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54.Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. | ||||
Ref 527645 | J Med Chem. 2005 Jul 28;48(15):4834-41.Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors. | ||||
Ref 527654 | Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33.Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. |
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