Drug Information

Drug General Information
Drug ID
D07FSW
Former ID
DNC000110
Drug Name
8-hydroxyguanine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535179]
Structure
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2D MOL

3D MOL
Formula
C5H5N5O2
Canonical SMILES
C12=C(NC(=NC1=O)N)NC(=O)N2
InChI
1S/C5H5N5O2/c6-4-8-2-1(3(11)10-4)7-5(12)9-2/h(H5,6,7,8,9,10,11,12)
InChIKey
CLGFIVUFZRGQRP-UHFFFAOYSA-N
PubChem Compound ID
65154
PubChem Substance ID
84843, 3135546, 4919642, 6311397, 6544738, 8189550, 14769547, 14818416, 22395071, 26753825, 32454889, 43121991, 49749828, 50068032, 51072119, 53790256, 57315354, 58689355, 76591018, 81058842, 96022321, 104333031, 118306573, 118520281, 119524940, 123059939, 125607996, 126524307, 127641595, 132504690, 134223896, 135023124, 135824301, 135935257, 136001735, 137008330, 137088829, 137137984, 142354401, 142562192, 143306708, 143431404, 143526144, 145468784, 160826234, 162232895, 162876233, 163128990, 163311900, 163840978
Target and Pathway
Target(s) GTP cyclohydrolase I Target Info Inhibitor [535179]
PathWhiz Pathway Pterine Biosynthesis
Reactome Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
References
Ref 535179GTP cyclohydrolase I feedback regulatory protein-dependent and -independent inhibitors of GTP cyclohydrolase I. Arch Biochem Biophys. 2001 Apr 1;388(1):67-73.
Ref 535179GTP cyclohydrolase I feedback regulatory protein-dependent and -independent inhibitors of GTP cyclohydrolase I. Arch Biochem Biophys. 2001 Apr 1;388(1):67-73.

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