Drug Information

Drug General Information
Drug ID
D06HSC
Former ID
DNC007651
Drug Name
Folate gamma-L-phenylalaninehydroxamic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528548]
Structure
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2D MOL

3D MOL
Formula
C28H29N9O7
Canonical SMILES
C1=CC=C(C=C1)CC(C(=O)NO)NC(=O)CCC(C(=O)O)NC(=O)C2=CC=C(<br />C=C2)NCC3=CN=C4C(=N3)C(=O)N=C(N4)N
InChI
1S/C28H29N9O7/c29-28-35-23-22(26(41)36-28)32-18(14-31-23)13-30-17-8-6-16(7-9-17)24(39)34-19(27(42)43)10-11-21(38)33-20(25(40)37-44)12-15-4-2-1-3-5-15/h1-9,14,19-20,30,44H,10-13H2,(H,33,38)(H,34,39)(H,37,40)(H,42,43)(H3,29,31,35,36,41)/t19-,20-/m0/s1
InChIKey
WYBGJFMKGROIBY-PMACEKPBSA-N
PubChem Compound ID
44428653
Target and Pathway
Target(s) Matrilysin Target Info Inhibitor [528548]
KEGG Pathway Wnt signaling pathway
NetPath Pathway Wnt Signaling Pathway
PANTHER Pathway Alzheimer disease-presenilin pathway
Wnt signaling pathway
CCKR signaling map ST
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Syndecan-1-mediated signaling events
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
WikiPathways Wnt Signaling Pathway and Pluripotency
Activation of Matrix Metalloproteinases
AGE/RAGE pathway
Matrix Metalloproteinases
References
Ref 528548Bioorg Med Chem. 2007 Feb 1;15(3):1266-74. Epub 2006 Nov 14.Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs.
Ref 528548Bioorg Med Chem. 2007 Feb 1;15(3):1266-74. Epub 2006 Nov 14.Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs.

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