| Drug General Information |
| Drug ID |
D06CMJ
|
| Former ID |
DNC010640
|
| Drug Name |
Para-chloroamphetamine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C9H12ClN
|
| InChI |
InChI=1S/C9H12ClN/c1-7(11)6-8-2-4-9(10)5-3-8/h2-5,7H,6,11H2,1H3
|
| InChIKey |
WWPITPSIWMXDPE-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
144422, 3221185, 7646846, 7980249, 8151993, 11406747, 15437689, 29222269, 30369885, 49880045, 50065008, 57321628, 75126043, 89084752, 99300564, 103392557, 103843885, 103938193, 104302600, 104706350, 117463198, 126407537, 129644874, 131324646, 134347845, 134971965, 135176785, 137009698, 142324085, 162210641, 162223123, 162889059, 170539229, 174534479, 177348006, 178101313, 179688084, 215795823, 221672779, 224007800, 226614389, 241108764, 249550220, 249911618
|
| Target and Pathway |
| Target(s) |
Sodium-dependent serotonin transporter |
Target Info |
Inhibitor |
[2]
|
|---|
| Sodium-dependent dopamine transporter |
Target Info |
Inhibitor |
[2]
|
| Sodium-dependent noradrenaline transporter |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
Serotonergic synapsehsa04728:Dopaminergic synapse
|
|
Parkinson's disease
|
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Cocaine addiction
|
|
Amphetamine addiction
|
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Alcoholism
|
|
NetPath Pathway
|
TCR Signaling Pathway
|
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PANTHER Pathway
|
5HT1 type receptor mediated signaling pathway
|
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5HT2 type receptor mediated signaling pathway
|
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5HT3 type receptor mediated signaling pathway
|
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5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
|
|
Parkinson disease
|
|
Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
|
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Pathway Interaction Database
|
Alpha-synuclein signaling
|
|
Reactome
|
Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
|
|
WikiPathways
|
Monoamine Transport
|
|
SIDS Susceptibility Pathways
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NRF2 pathway
|
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Synaptic Vesicle Pathway
|
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Serotonin Transporter ActivityWP727:Monoamine Transport
|
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Dopaminergic Neurogenesis
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Parkinsons Disease Pathway
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Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
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Neurotransmitter Clearance In The Synaptic CleftWP727:Monoamine Transport
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4592). |
|---|
| REF 2 | Eur J Med Chem. 2009 Dec;44(12):4862-88. Epub 2009 Aug 6.Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. |
|---|
