Drug General Information
Drug ID
D05TIB
Former ID
DAP000342
Drug Name
Trospium
Synonyms
Spasmex; Spasmoplex; Trosec; Trospium chloride; IP-631; Regurin (TN); Sanctura (TN); Spasmex (TN); Spasmoplex (TN); Trosec (TN); Trospium chloride (JAN/USAN/INN); Spiro(8-azoniabicyclo(3.2.1)octane-8,1'-pyrrolidinium), 3-hydroxy-, chloride, benzilate; Spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl 2-hydroxy-2,2-diphenylacetate; Spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl 2-hydroxy-2,2-diphenylacetate chloride; 3-Hydroxyspiro(8-azoniabicyclo(3.2.1)octane-8,1'-pyrrolidinium) chloride benzilate; 6,10-Ethano-5-azoniaspiro(4.5)decan-8-ol, chloride, benzilate; 8-Benziloyloxy-6,10-ethano-5-azoniaspiro(4.5)decane chloride
Drug Type
Small molecular drug
Indication Overactive bladder disorder; Spasm [ICD9: 188, 596.51, 728.85; ICD10:C67, N32.81, R25.2] Approved [527466], [528278], [538569], [542503], [551871]
Therapeutic Class
Parasympatholytics
Company
Allergan Pharmaceuticals
Structure
Download
2D MOL

3D MOL

Formula
C25H30NO3+
InChI
InChI=1S/C25H30NO3/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26/h1-6,9-12,21-23,28H,7-8,13-18H2/q+1
InChIKey
OYYDSUSKLWTMMQ-UHFFFAOYSA-N
CAS Number
CAS 10405-02-4
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
G04BD09
SuperDrug CAS ID
cas=010405024
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M5 Target Info Antagonist [536284]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 5274662004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4.
Ref 528278Trospium chloride: the European experience. Expert Opin Pharmacother. 2006 Jul;7(10):1373-80.
Ref 538569FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 021595.
Ref 542503(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7480).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536284Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.

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