Drug General Information
Drug ID	D05QUG
Former ID	DNC010065
Drug Name	7-phenethoxy-2H-chromen-2-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530514]
Structure		Download 2D MOL 3D MOL
Formula	C17H14O2
Canonical SMILES	C1=CC=C(C=C1)CCC2=CC3=C(C=C2)C=CC(=O)O3
InChI	1S/C17H14O2/c18-17-11-10-15-9-8-14(12-16(15)19-17)7-6-13-4-2-1-3-5-13/h1-5,8-12H,6-7H2
InChIKey	FQWWPSNGCTYUHH-UHFFFAOYSA-N
PubChem Compound ID	45485279
Target and Pathway
Target(s)	Carbonic anhydrase	Target Info	Inhibitor	[530514]
	Carbonic anhydrase XII	Target Info	Inhibitor	[530514]
	Carbonic anhydrase IX	Target Info	Inhibitor	[530514]
	Carbonic anhydrase XIV	Target Info	Inhibitor	[530514]
KEGG Pathway	Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database	HIF-1-alpha transcription factor network
Reactome	Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
	Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxide
WikiPathways	Reversible Hydration of Carbon Dioxide
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in leukocytes - TarBase
	miR-targeted genes in epithelium - TarBaseWP2877:Vitamin D Receptor Pathway
	Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide
References
Ref 530514	J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 530514	J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.

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