| Drug General Information |
| Drug ID |
D05JPV
|
| Former ID |
DNC006096
|
| Drug Name |
4-(4-(dec-1-ynyl)phenyl)-4-oxobutanoic acid
|
| Drug Type |
Small molecular drug
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| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C20H26O3
|
| Canonical SMILES |
CCCCCCCCC#CC1=CC=C(C=C1)C(=O)CCC(=O)O
|
| InChI |
1S/C20H26O3/c1-2-3-4-5-6-7-8-9-10-17-11-13-18(14-12-17)19(21)15-16-20(22)23/h11-14H,2-8,15-16H2,1H3,(H,22,23)
|
| InChIKey |
JJPRJMIBECZYNN-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
MMP-12 |
Target Info |
Inhibitor |
[1]
|
|---|
| 72 kDa type IV collagenase |
Target Info |
Inhibitor |
[1]
|
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KEGG Pathway
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Leukocyte transendothelial migration
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GnRH signaling pathway
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Estrogen signaling pathway
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Pathways in cancer
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Proteoglycans in cancer
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Bladder cancer
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NetPath Pathway
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IL1 Signaling Pathway
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IL5 Signaling PathwayNetPath_22:Leptin Signaling Pathway
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TCR Signaling Pathway
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ID Signaling Pathway
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PANTHER Pathway
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Alzheimer disease-presenilin pathway
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Pathway Interaction Database
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalinglysophospholipid_pathway:LPA receptor mediated events
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Plasma membrane estrogen receptor signaling
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Osteopontin-mediated events
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Validated transcriptional targets of AP1 family members Fra1 and Fra2
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Angiopoietin receptor Tie2-mediated signaling
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Direct p53 effectors
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amb2 Integrin signaling
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ATF-2 transcription factor network
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FOXM1 transcription factor network
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Regulation of nuclear beta catenin signaling and target gene transcription
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Syndecan-2-mediated signaling events
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Reactome
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Collagen degradation
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Degradation of the extracellular matrixR-HSA-1442490:Collagen degradation
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Degradation of the extracellular matrix
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Activation of Matrix Metalloproteinases
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Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
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EPH-ephrin mediated repulsion of cells
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WikiPathways
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TGF beta Signaling Pathway
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Degradation of collagen
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Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
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AGE/RAGE pathway
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Matrix Metalloproteinases
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| References |
| REF 1 | J Med Chem. 2006 Jan 26;49(2):456-8.Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids. |
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