Drug Information

Drug General Information
Drug ID
D04VMT
Former ID
DAP000372
Drug Name
Sotalol
Synonyms
Sotalolum; Darob mite; Sotalol Monohydrochloride; Beta-Cardone; Betapace (TN); Betapace AF (TN); Darob mite (TN); MJ-1999; Sotacor (TN); Sotalex (TN); Sotalol (INN); Sotalol [INN:BAN]; Sotalolum [INN-Latin]; D,l-Sotalol; N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide; N-(4-{1-hydroxy-2-[(1-methylethyl)amino]ethyl}phenyl)methanesulfonamide; N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide; Methanesulfonamide, N-(4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)phenyl)-(9CI); 4'-(1-Hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide; 4'-(1-Hydroxy-2-isopropylaminoethyl)methanesulfonanilid
Drug Type
Small molecular drug
Indication Maintenance of normal sinus rhythm [ICD9: 427; ICD10:I46-I49] Approved [536095], [542317]
Therapeutic Class
Antiarrhythmic Agents
Company
Bristol-Myers Squibb
Structure
Download
2D MOL

3D MOL
Formula
C12H20N2O3S
InChI
InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3
InChIKey
ZBMZVLHSJCTVON-UHFFFAOYSA-N
CAS Number
CAS 3930-20-9
PubChem Compound ID
5253
PubChem Substance ID
9517, 3221867, 5612028, 7980639, 8153233, 10521436, 11466994, 11468114, 11486628, 14775037, 26751989, 29224308, 46505012, 47730756, 47879636, 48029202, 48029203, 48253453, 48416548, 49699392, 49991262, 50104666, 53790038, 56413050, 57288838, 57322681, 80811639, 85220240, 85788914, 90341280, 92308885, 92717147, 96025210, 103168744, 104171235, 104308703, 118314017, 124750203, 124881382, 124881383, 124881384, 125349604, 126622467, 128364869, 129878952, 134337682, 134985209, 135610135, 137100765, 142466945
SuperDrug ATC ID
C07AA07
SuperDrug CAS ID
cas=003930209
Target and Pathway
Target(s) Beta-1 adrenergic receptor Target Info Antagonist [537126]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Gap junction
Salivary secretion
Dilated cardiomyopathy
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta1 adrenergic receptor signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
References
Ref 536095New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22.
Ref 542317(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7297).
Ref 537126beta(2)-adrenoceptors are critical for antidepressant treatment of neuropathic pain. Ann Neurol. 2009 Feb;65(2):218-25.

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