| Drug General Information |
| Drug ID |
D04SVB
|
| Former ID |
DIB015535
|
| Drug Name |
FR-133605
|
| Indication |
Arthritis [ICD9: 710-719; ICD10:M00-M25]
|
Terminated |
[1]
|
|---|
| Company |
Fujisawa Pharmaceutical Co Ltd
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Canonical SMILES |
n1c(c(n2c1NCCN2)c1ccncc1)c1ccc(cc1)F
|
| CAS Number |
CAS 144752-64-7
|
| Target and Pathway |
| Target(s) |
Tumor necrosis factor |
Target Info |
Modulator |
[1]
|
|---|
| Interleukin-1 receptor, type II |
Target Info |
Modulator |
[1]
|
|
KEGG Pathway
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MAPK signaling pathway
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Cytokine-cytokine receptor interaction
|
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NF-kappa B signaling pathway
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Sphingolipid signaling pathway
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mTOR signaling pathway
|
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Apoptosis
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TGF-beta signaling pathway
|
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Osteoclast differentiation
|
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Antigen processing and presentation
|
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Toll-like receptor signaling pathway
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NOD-like receptor signaling pathway
|
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RIG-I-like receptor signaling pathway
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Hematopoietic cell lineage
|
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Natural killer cell mediated cytotoxicity
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T cell receptor signaling pathway
|
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Fc epsilon RI signaling pathway
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TNF signaling pathway
|
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Adipocytokine signaling pathway
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Type II diabetes mellitus
|
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Non-alcoholic fatty liver disease (NAFLD)
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Type I diabetes mellitus
|
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Alzheimer's disease
|
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Amyotrophic lateral sclerosis (ALS)
|
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Pertussis
|
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Legionellosis
|
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Leishmaniasis
|
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Chagas disease (American trypanosomiasis)
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African trypanosomiasis
|
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Malaria
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Toxoplasmosis
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Amoebiasis
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Tuberculosis
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Hepatitis C
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Hepatitis B
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Influenza A
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HTLV-I infection
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Herpes simplex infection
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Proteoglycans in cancer
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Asthma
|
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Inflammatory bowel disease (IBD)
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Systemic lupus erythematosus
|
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Rheumatoid arthritis
|
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Allograft rejection
|
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Graft-versus-host disease
|
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Hypertrophic cardiomyopathy (HCM)
|
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Dilated cardiomyopathyhsa04010:MAPK signaling pathway
|
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Transcriptional misregulation in cancer
|
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NetPath Pathway
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TCR Signaling Pathway
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IL2 Signaling Pathway
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IL3 Signaling Pathway
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IL4 Signaling Pathway
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Leptin Signaling Pathway
|
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RANKL Signaling Pathway
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IL1 Signaling PathwayNetPath_13:IL1 Signaling Pathway
|
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TNFalpha Signaling Pathway
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PANTHER Pathway
|
Apoptosis signaling pathway
|
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Wnt signaling pathway
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Pathway Interaction Database
|
IL27-mediated signaling events
|
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Canonical NF-kappaB pathway
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
|
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Angiopoietin receptor Tie2-mediated signaling
|
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Signaling events mediated by HDAC Class I
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TNF receptor signaling pathway
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Ceramide signaling pathway
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amb2 Integrin signaling
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RXR and RAR heterodimerization with other nuclear receptor
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IL23-mediated signaling events
|
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HIV-1 Nef: Negative effector of Fas and TNF-alpha
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Caspase Cascade in Apoptosis
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Cellular roles of Anthrax toxin
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Downstream signaling in naï
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IL1-mediated signaling events
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PathWhiz Pathway
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Fc Epsilon Receptor I Signaling in Mast Cells
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Reactome
|
Transcriptional regulation of white adipocyte differentiation
|
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TNFR1-induced proapoptotic signaling
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Regulation of TNFR1 signaling
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TNFR1-induced NFkappaB signaling pathway
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TNFR1-mediated ceramide production
|
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TNFR2 non-canonical NF-kB pathway
|
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TNF signalingR-HSA-446652:Interleukin-1 signaling
|
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WikiPathways
|
Toll-like receptor signaling pathway
|
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Monoamine Transport
|
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SIDS Susceptibility Pathways
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TGF Beta Signaling Pathway
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Cytokines and Inflammatory Response
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MAPK Signaling Pathway
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EV release from cardiac cells and their functional effects
|
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FAS pathway and Stress induction of HSP regulation
|
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Apoptosis-related network due to altered Notch3 in ovarian cancer
|
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Cardiac Hypertrophic Response
|
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Transcriptional Regulation of White Adipocyte Differentiation
|
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Aryl Hydrocarbon Receptor
|
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Apoptosis
|
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Nanoparticle triggered regulated necrosis
|
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Amyotrophic lateral sclerosis (ALS)
|
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Adipogenesis
|
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Allograft Rejection
|
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TNF alpha Signaling Pathway
|
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TWEAK Signaling Pathway
|
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Extrinsic Pathway for Apoptosis
|
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Folate Metabolism
|
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MicroRNAs in cardiomyocyte hypertrophy
|
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Vitamin B12 Metabolism
|
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Selenium Micronutrient Network
|
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Regulation of toll-like receptor signaling pathway
|
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Matrix MetalloproteinasesWP382:MAPK Signaling Pathway
|
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Interleukin-1 signaling
|
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Apoptosis Modulation and Signaling
|
| References |
| REF 1 | Effect of FR133605, a novel cytokine suppressive agent, on bone and cartilage destruction in adjuvant arthritic rats. J Rheumatol. 1996 Oct;23(10):1778-83. |
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