Drug Information
Drug General Information | |||||
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Drug ID |
D04SNH
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Former ID |
DNC011193
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Drug Name |
1-Benzyl-1,4-dihydro-4-oxo-3-pyridinesulfonamide
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [530978] | ||
Structure |
Download2D MOL |
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Formula |
C12H12N2O3S
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Canonical SMILES |
C1=CC=C(C=C1)CN2C=CC(=O)C(=C2)S(=O)(=O)N
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InChI |
1S/C12H12N2O3S/c13-18(16,17)12-9-14(7-6-11(12)15)8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H2,13,16,17)
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InChIKey |
WIIFYOJVUKTZDG-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Carbonic anhydrase XII | Target Info | Inhibitor | [530978] | |
Carbonic anhydrase II | Target Info | Inhibitor | [530978] | ||
Carbonic anhydrase I | Target Info | Inhibitor | [530978] | ||
Carbonic anhydrase IX | Target Info | Inhibitor | [530978] | ||
Pathway Interaction Database | C-MYB transcription factor networkhif1_tfpathway:HIF-1-alpha transcription factor network | ||||
PathWhiz Pathway | Gastric Acid Production | ||||
Reactome | Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen | ||||
Erythrocytes take up oxygen and release carbon dioxide | |||||
Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor | |||||
Reversible hydration of carbon dioxide | |||||
WikiPathways | Reversible Hydration of Carbon Dioxide | ||||
miR-targeted genes in muscle cell - TarBase | |||||
miR-targeted genes in leukocytes - TarBase | |||||
miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon Dioxide | |||||
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | |||||
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide | |||||
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2877:Vitamin D Receptor Pathway | |||||
Regulation of Hypoxia-inducible Factor (HIF) by Oxygen | |||||
References | |||||
Ref 530978 | Eur J Med Chem. 2010 Sep;45(9):3656-61. Epub 2010 May 12.Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII. | ||||
Ref 530978 | Eur J Med Chem. 2010 Sep;45(9):3656-61. Epub 2010 May 12.Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII. |
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