| Drug General Information |
| Drug ID |
D04OHM
|
| Former ID |
DNC012466
|
| Drug Name |
4-cyclopentyliden(4-hydroxyphenyl)methylphenol
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| Drug Type |
Small molecular drug
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| Indication |
Discovery agent
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Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C18H18O2
|
| Canonical SMILES |
C1CCC(=C(C2=CC=C(C=C2)O)C3=CC=C(C=C3)O)C1
|
| InChI |
1S/C18H18O2/c19-16-9-5-14(6-10-16)18(13-3-1-2-4-13)15-7-11-17(20)12-8-15/h5-12,19-20H,1-4H2
|
| InChIKey |
GIGYKXHGYNZBEN-UHFFFAOYSA-N
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| PubChem Compound ID |
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| Target and Pathway |
| Target(s) |
Protein kinase C gamma type |
Target Info |
Inhibitor |
[1]
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|---|
| Protein kinase C, beta type |
Target Info |
Inhibitor |
[1]
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| Protein kinase C, alpha type |
Target Info |
Inhibitor |
[1]
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KEGG Pathway
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MAPK signaling pathway
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ErbB signaling pathway
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Ras signaling pathway
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Rap1 signaling pathway
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Calcium signaling pathway
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HIF-1 signaling pathway
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Phosphatidylinositol signaling system
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Sphingolipid signaling pathway
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mTOR signaling pathway
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Vascular smooth muscle contraction
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Wnt signaling pathway
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VEGF signaling pathway
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Focal adhesion
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Tight junction
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Gap junction
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Natural killer cell mediated cytotoxicity
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Fc gamma R-mediated phagocytosis
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Leukocyte transendothelial migration
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Circadian entrainment
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Long-term potentiation
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Retrograde endocannabinoid signaling
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Glutamatergic synapse
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Cholinergic synapse
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Serotonergic synapse
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GABAergic synapse
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Dopaminergic synapse
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Long-term depression
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Inflammatory mediator regulation of TRP channels
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Insulin secretion
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Melanogenesis
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Thyroid hormone synthesis
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Thyroid hormone signaling pathway
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Oxytocin signaling pathway
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Aldosterone-regulated sodium reabsorption
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Endocrine and other factor-regulated calcium reabsorption
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Salivary secretion
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Gastric acid secretion
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Pancreatic secretion
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Amphetamine addiction
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Morphine addiction
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Vibrio cholerae infection
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African trypanosomiasis
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Amoebiasis
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Hepatitis B
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Pathways in cancer
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Proteoglycans in cancer
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MicroRNAs in cancer
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Glioma
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Non-small cell lung cancer
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Choline metabolism in cancerhsa04010:MAPK signaling pathway
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Chemokine signaling pathway
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NF-kappa B signaling pathway
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B cell receptor signaling pathway
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Fc epsilon RI signaling pathway
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GnRH signaling pathway
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Carbohydrate digestion and absorption
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Leishmaniasis
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Influenza A
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PI3K-Akt signaling pathway
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Adrenergic signaling in cardiomyocytes
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Pathogenic Escherichia coli infection
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Choline metabolism in cancer
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NetPath Pathway
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IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
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PANTHER Pathway
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Alpha adrenergic receptor signaling pathway
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Alzheimer disease-amyloid secretase pathway
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Angiogenesis
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Apoptosis signaling pathway
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EGF receptor signaling pathway
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Endothelin signaling pathway
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FGF signaling pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
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VEGF signaling pathway
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Wnt signaling pathway
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5HT2 type receptor mediated signaling pathway
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Histamine H1 receptor mediated signaling pathway
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Oxytocin receptor mediated signaling pathway
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Thyrotropin-releasing hormone receptor signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
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B cell activation
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Inflammation mediated by chemokine and cytokine signaling pathway
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Metabotropic glutamate receptor group I pathway
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Thyrotropin-releasing hormone receptor signaling pathway
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CCKR signaling map STP00002:Alpha adrenergic receptor signaling pathway
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PDGF signaling pathway
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Angiotensin II-stimulated signaling through G proteins and beta-arrestin
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CCKR signaling map ST
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Pathway Interaction Database
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Endothelins
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Thromboxane A2 receptor signaling
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Retinoic acid receptors-mediated signaling
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IL8- and CXCR2-mediated signaling events
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PAR1-mediated thrombin signaling events
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IL8- and CXCR1-mediated signaling eventsfcer1pathway:Fc-epsilon receptor I signaling in mast cells
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TCR signaling in naï
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TCR signaling in naï
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IL2-mediated signaling events
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Ras signaling in the CD4+ TCR pathway
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JNK signaling in the CD4+ TCR pathway
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Regulation of Ras family activation
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Downstream signaling in naï
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Endothelins
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Canonical NF-kappaB pathway
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Signaling events regulated by Ret tyrosine kinase
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mTOR signaling pathway
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ErbB1 downstream signaling
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Syndecan-4-mediated signaling events
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ATF-2 transcription factor network
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PDGFR-beta signaling pathway
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VEGFR1 specific signals
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Signaling events mediated by VEGFR1 and VEGFR2
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a6b1 and a6b4 Integrin signaling
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IL8- and CXCR1-mediated signaling events
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PathWhiz Pathway
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Fc Epsilon Receptor I Signaling in Mast Cells
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Activation of PKC through G protein coupled receptor
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Reactome
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Calmodulin induced events
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Disinhibition of SNARE formation
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Trafficking of GluR2-containing AMPA receptors
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G alpha (z) signalling events
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WNT5A-dependent internalization of FZD4
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Response to elevated platelet cytosolic Ca2+R-HSA-114516:Disinhibition of SNARE formation
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Activation of NF-kappaB in B cells
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Depolymerisation of the Nuclear Lamina
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VEGFR2 mediated cell proliferation
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Response to elevated platelet cytosolic Ca2+R-HSA-111933:Calmodulin induced events
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Regulation of KIT signaling
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EGFR Transactivation by Gastrin
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Inactivation, recovery and regulation of the phototransduction cascade
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Syndecan interactions
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Acetylcholine regulates insulin secretion
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Ca2+ pathway
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HuR (ELAVL1) binds and stabilizes mRNA
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Response to elevated platelet cytosolic Ca2+
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WikiPathways
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Calcium Regulation in the Cardiac Cell
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Wnt Signaling Pathway
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Wnt Signaling Pathway and Pluripotency
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MAPK Signaling Pathway
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Wnt Signaling Pathway Netpath
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G Protein Signaling Pathways
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Myometrial Relaxation and Contraction Pathways
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DAG and IP3 signaling
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Signaling Pathways in Glioblastoma
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miRs in Muscle Cell Differentiation
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Opioid Signalling
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Response to elevated platelet cytosolic Ca2+WP536:Calcium Regulation in the Cardiac Cell
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Insulin Signaling
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EGF/EGFR Signaling Pathway
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Kit receptor signaling pathway
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Signaling by the B Cell Receptor (BCR)
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Oncostatin M Signaling Pathway
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Corticotropin-releasing hormone
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AGE/RAGE pathway
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B Cell Receptor Signaling Pathway
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Response to elevated platelet cytosolic Ca2+
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MicroRNAs in cardiomyocyte hypertrophy
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Physiological and Pathological Hypertrophy of the HeartWP673:ErbB Signaling Pathway
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Transcriptional activation by NRF2
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Human Complement System
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Cardiac Hypertrophic Response
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Syndecan interactions
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Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
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Signaling by SCF-KIT
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Gastrin-CREB signalling pathway via PKC and MAPK
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T-Cell Receptor and Co-stimulatory Signaling
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Alpha 6 Beta 4 signaling pathway
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Spinal Cord Injury
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Integrated Pancreatic Cancer Pathway
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Pathogenic Escherichia coli infection
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Endothelin Pathways
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Regulation of Microtubule Cytoskeleton
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FSH signaling pathway
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Integration of energy metabolism
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TOR Signaling
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| References |
| REF 1 | J Med Chem. 1992 Feb 7;35(3):573-83.Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation. |
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