Drug General Information
Drug ID	D04HQP
Former ID	DNC006437
Drug Name	N,N-dimethyl-4-(pyridin-3-yl)but-3-yn-1-amine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527965]
Structure		Download 2D MOL 3D MOL
Formula	C11H14N2
Canonical SMILES	CN(C)CCC#CC1=CN=CC=C1
InChI	1S/C11H14N2/c1-13(2)9-4-3-6-11-7-5-8-12-10-11/h5,7-8,10H,4,9H2,1-2H3
InChIKey	SGURIVLPISZAAK-UHFFFAOYSA-N
PubChem Compound ID	44366245
Target and Pathway
Target(s)	Neuronal acetylcholine receptor protein, alpha-4 chain	Target Info	Inhibitor	[527965]
	Neuronal acetylcholine receptor protein, beta-2 chain	Target Info	Inhibitor	[527965]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Cholinergic synapse
	Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
	Nicotine addiction
PANTHER Pathway	Nicotinic acetylcholine receptor signaling pathway
	Nicotine pharmacodynamics pathwayP00044:Nicotinic acetylcholine receptor signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Highly sodium permeable acetylcholine nicotinic receptors
	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
	Highly calcium permeable nicotinic acetylcholine receptorsR-HSA-629587:Highly sodium permeable acetylcholine nicotinic receptors
	Highly calcium permeable nicotinic acetylcholine receptors
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Nicotine Activity on Dopaminergic NeuronsWP706:SIDS Susceptibility Pathways
	Nicotine Activity on Dopaminergic Neurons
References
Ref 527965	Bioorg Med Chem Lett. 2006 Apr 1;16(7):2013-6. Epub 2006 Jan 18.Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594.
Ref 527965	Bioorg Med Chem Lett. 2006 Apr 1;16(7):2013-6. Epub 2006 Jan 18.Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594.

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