Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04AWP
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| Former ID |
DNC003225
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| Drug Name |
Guanosine-5'-Monophosphate
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C10H14N5O8P
|
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| InChI |
InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
|
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| InChIKey |
RQFCJASXJCIDSX-UUOKFMHZSA-N
|
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| CAS Number |
CAS 85-32-5
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| PubChem Compound ID | |||||
| PubChem Substance ID |
3444, 624118, 819062, 819405, 820462, 820497, 820533, 821796, 821952, 822752, 822753, 823075, 823149, 823150, 823869, 826036, 830674, 830999, 838629, 841773, 855181, 7885411, 7886738, 7887674, 8145524, 10317424, 10322321, 10322546, 11538719, 14901517, 16002058, 16014337, 24424483, 26705126, 26710788, 26712698, 26715076, 26717730, 26718716, 26736956, 29214752, 29225748, 46391986, 46393006, 46393137, 46393444, 46394156, 46530280, 49655320, 49975004
|
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| Target and Pathway | |||||
| Target(s) | DNA polymerase | Target Info | Inhibitor | [2] | |
| CGMP-specific 3',5'-cyclic phosphodiesterase | Target Info | Inhibitor | [2] | ||
| DNA polymerase (HSV-2) | Target Info | Inhibitor | [2] | ||
| HCMV DNA polymerase | Target Info | Inhibitor | [2] | ||
| Hypoxanthine-guanine phosphoribosyltransferase | Target Info | Inhibitor | [2] | ||
| Presynaptic density protein 95 | Target Info | Inhibitor | [2] | ||
| KEGG Pathway | Purine metabolism | ||||
| cGMP-PKG signaling pathwayhsa00230:Purine metabolism | |||||
| Drug metabolism - other enzymes | |||||
| Metabolic pathwayshsa04390:Hippo signaling pathway | |||||
| Glutamatergic synapse | |||||
| Huntington's disease | |||||
| Cocaine addiction | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| PANTHER Pathway | Huntington disease | ||||
| Pathway Interaction Database | ErbB4 signaling events | ||||
| PathWhiz Pathway | Purine Metabolism | ||||
| Reactome | cGMP effectsR-HSA-74217:Purine salvageR-HSA-399719:Trafficking of AMPA receptors | ||||
| Unblocking of NMDA receptor, glutamate binding and activation | |||||
| CREB phosphorylation through the activation of CaMKII | |||||
| Ras activation uopn Ca2+ infux through NMDA receptor | |||||
| RHO GTPases activate CIT | |||||
| RAF/MAP kinase cascade | |||||
| WikiPathways | Nucleotide Metabolism | ||||
| Mesodermal Commitment Pathway | |||||
| Endoderm Differentiation | |||||
| Metabolism of nucleotidesWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| L1CAM interactions | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5123). | ||||
| REF 2 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
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