Drug Information

Drug General Information
Drug ID
D03XTC
Former ID
DAP000304
Drug Name
Esmolol
Synonyms
ASL 8052-001; Brevibloc (TN); Esmolol (INN); Esmolol [INN:BAN]; Methyl p-[2-hydroxy-3-(isopropylamino)propoxy]hydrocinnamate; Methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate; Methyl 3-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]propanoate; Methyl 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoate; Methyl 3-[4-({2-hydroxy-3-[(1-methylethyl)amino]propyl}oxy)phenyl]propanoate; Methyl 3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoate; Benzenepropanoic acid, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, methyl ester; (+-)-Esmolol; (+-)-methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate
Drug Type
Small molecular drug
Indication Acute supraventricular tachycardia [ICD9: 427.0, 427.89; ICD10:I47.1] Approved [536361], [542188]
Therapeutic Class
Antihypertensive Agents
Company
Bedford Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C16H25NO4
InChI
InChI=1S/C16H25NO4/c1-12(2)17-10-14(18)11-21-15-7-4-13(5-8-15)6-9-16(19)20-3/h4-5,7-8,12,14,17-18H,6,9-11H2,1-3H3
InChIKey
AQNDDEOPVVGCPG-UHFFFAOYSA-N
CAS Number
CAS 103598-03-4
PubChem Compound ID
59768
PubChem Substance ID
9194, 7435390, 7979187, 8186499, 14825011, 43117267, 46506146, 48415954, 49881073, 50068830, 50307609, 57313969, 85209983, 92309302, 92711342, 96024612, 99313645, 103203672, 104319031, 117553531, 124896652, 124896653, 126422058, 126630958, 126683075, 126684165, 127444743, 134337616, 135018086, 135060484, 137252284, 137862731, 141092871, 152100153, 160963535, 162179020, 163134401, 163353820, 176484552, 178103753, 179151222, 179500095, 184675752, 211535411, 223653372, 223682206, 223837113, 226395749, 241162565, 250133519
SuperDrug ATC ID
C07AB09
SuperDrug CAS ID
cas=081147924
Target and Pathway
Target(s) Beta-1 adrenergic receptor Target Info Antagonist [537023]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Gap junction
Salivary secretion
Dilated cardiomyopathy
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta1 adrenergic receptor signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 542188(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7178).
Ref 537023Beta-1 selective adrenergic antagonist landiolol and esmolol can be safely used in patients with airway hyperreactivity. Heart Lung. 2009 Jan-Feb;38(1):48-55. Epub 2008 Sep 11.

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