Drug Information

Drug General Information
Drug ID
D03TPB
Former ID
DNC007320
Drug Name
1-[bis(4-iodophenyl)methyl]-3-(4-bromophenyl)urea
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527861]
Structure
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2D MOL

3D MOL
Formula
C20H15BrI2N2O
Canonical SMILES
C1=CC(=CC=C1C(C2=CC=C(C=C2)I)NC(=O)NC3=CC=C(C=C3)Br)I
InChI
1S/C20H15BrI2N2O/c21-15-5-11-18(12-6-15)24-20(26)25-19(13-1-7-16(22)8-2-13)14-3-9-17(23)10-4-14/h1-12,19H,(H2,24,25,26)
InChIKey
ALTGZVPJBKOZHG-UHFFFAOYSA-N
PubChem Compound ID
11498260
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Inhibitor [527861]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 527861J Med Chem. 2005 Nov 17;48(23):7486-90.1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: new templates among the CB1 cannabinoid receptor inverse agonists.
Ref 527861J Med Chem. 2005 Nov 17;48(23):7486-90.1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: new templates among the CB1 cannabinoid receptor inverse agonists.

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