Drug General Information
Drug ID	D03RXH
Former ID	DNC008510
Drug Name	SALICYLATE
Drug Type	Small molecular drug
Indication	Discovery agent		Phase 4	[524105]
Structure		Download 2D MOL 3D MOL
Formula	C7H6O3
Canonical SMILES	C1=CC=C(C(=C1)C(=O)O)O
InChI	1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)
InChIKey	YGSDEFSMJLZEOE-UHFFFAOYSA-N
CAS Number	CAS 69-72-7
PubChem Compound ID	338
Target and Pathway
Target(s)	Carbonic anhydrase VI	Target Info	Inhibitor	[529562]
	Carbonic anhydrase XII	Target Info	Inhibitor	[529562]
	Carbonic anhydrase II	Target Info	Inhibitor	[529562]
	Carbonic anhydrase	Target Info	Inhibitor	[529489]
	Carbonic anhydrase IV	Target Info	Inhibitor	[529562]
	Carbonic anhydrase I	Target Info	Inhibitor	[529562]
KEGG Pathway	Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
	Proximal tubule bicarbonate reclamation
	Collecting duct acid secretion
	Gastric acid secretion
	Pancreatic secretion
	Bile secretionhsa00910:Nitrogen metabolism
	Proximal tubule bicarbonate reclamationhsa00910:Nitrogen metabolism
NetPath Pathway	TGF_beta_Receptor Signaling PathwayNetPath_16:IL4 Signaling Pathway
	EGFR1 Signaling Pathway
Pathway Interaction Database	C-MYB transcription factor network
PathWhiz Pathway	Gastric Acid Production
Reactome	Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
	Erythrocytes take up oxygen and release carbon dioxide
	Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
	Reversible hydration of carbon dioxide
WikiPathways	Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon Dioxide
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in leukocytes - TarBase
	miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon Dioxide
	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
	Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
	Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 524105	ClinicalTrials.gov (NCT01712295) 17% Salicylate Versus 17% Salicylate-Ethyl Pyruvate for Plantar Foot Warts. U.S. National Institutes of Health.
Ref 529489	Bioorg Med Chem Lett. 2008 Jun 15;18(12):3593-6. Epub 2008 May 4.Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.
Ref 529562	Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. Epub 2008 Jun 13.Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.

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