Drug Information

Drug General Information
Drug ID
D03RGV
Former ID
DNC007000
Drug Name
JWH-156
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528355]
Structure
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2D MOL

3D MOL
Formula
C24H21NO
Canonical SMILES
CCCN1C=C(C=C1C2=CC=CC=C2)C(=O)C3=CC=CC4=CC=CC=C43
InChI
1S/C24H21NO/c1-2-15-25-17-20(16-23(25)19-10-4-3-5-11-19)24(26)22-14-8-12-18-9-6-7-13-21(18)22/h3-14,16-17H,2,15H2,1H3
InChIKey
CVADUNUZYYADMA-UHFFFAOYSA-N
PubChem Compound ID
44418301
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Inhibitor [528355]
Cannabinoid receptor 2 Target Info Inhibitor [528355]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signalinghsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 528355Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. Epub 2006 Aug 4.1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors.
Ref 528355Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. Epub 2006 Aug 4.1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors.

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