| Drug General Information |
| Drug ID |
D02WTM
|
| Former ID |
DIB020633
|
| Drug Name |
oxotremorine-M
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Formula |
C11H19N2O+
|
| InChI |
InChI=1S/C11H19N2O/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14/h6-10H2,1-3H3/q+1
|
| InChIKey |
CANZROMYQDHYHR-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
5204098, 8152841, 11111561, 11113895, 11335554, 11360793, 11364948, 11367510, 11370072, 11378243, 11461765, 11495796, 15463058, 24712380, 29223718, 47216703, 47365114, 47736400, 47810672, 50065007, 50104710, 76120148, 85209218, 90340770, 103226553, 103835124, 103919129, 104306961, 117592577, 124750122, 124880946, 124880947, 135070391, 135650783, 179148737, 230462844, 252166796
|
| Target and Pathway |
| Target(s) |
Muscarinic receptor |
Target Info |
Agonist |
[2]
|
|---|
| Muscarinic acetylcholine receptor M3 |
Target Info |
Agonist |
[2]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
PI3K-Akt signaling pathway
|
|
Cholinergic synapse
|
|
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
|
|
Regulation of actin cytoskeleton
|
|
Insulin secretion
|
|
Salivary secretion
|
|
Gastric acid secretion
|
|
Pancreatic secretion
|
|
PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
|
PathWhiz Pathway
|
Muscle/Heart ContractionPW000565:Gastric Acid Production
|
|
Reactome
|
Muscarinic acetylcholine receptors
|
|
Acetylcholine regulates insulin secretion
|
|
G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
|
|
G alpha (q) signalling events
|
|
WikiPathways
|
Monoamine GPCRs
|
|
Calcium Regulation in the Cardiac Cell
|
|
Regulation of Actin Cytoskeleton
|
|
GPCRs, Class A Rhodopsin-like
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
Secretion of Hydrochloric Acid in Parietal Cells
|
|
GPCR ligand binding
|
|
GPCR downstream signalingWP58:Monoamine GPCRs
|
|
Integration of energy metabolism
|
|
GPCR downstream signaling
|
|
GPCRs, Other
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 303). |
|---|
| REF 2 | Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol. 1997 Jul;52(1):172-9. |
|---|
