Drug Information

Drug General Information
Drug ID
D02VSL
Former ID
DNC006040
Drug Name
JWH-133
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542494]
Structure
Download
2D MOL

3D MOL
Formula
C22H32O
InChI
InChI=1S/C22H32O/c1-7-12-21(3,4)16-9-10-17-18-13-15(2)8-11-19(18)22(5,6)23-20(17)14-16/h8-10,14,18-19H,7,11-13H2,1-6H3/t18-,19+/m0/s1
InChIKey
YSBFLLZNALVODA-RBUKOAKNSA-N
PubChem Compound ID
6918505
PubChem Substance ID
12015393, 15247833, 17194928, 24896193, 43529875, 53787464, 57371958, 80120607, 103476212, 104065174, 114788075, 134343245, 135290980, 135650450, 136946463, 141403571, 144116097, 162011710, 162222260, 172099118, 174528380, 186014474, 196378838, 227720191, 241055372, 241182345, 241375369, 245753696, 250107487, 252156090, 252160128
Target and Pathway
Target(s) Cannabinoid receptor 2 Target Info Inhibitor [528452]
Cannabinoid receptor 1 Target Info Inhibitor [531214]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04015:Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
BDNF signaling pathway
GPCR downstream signaling
GPCRs, Other
References
Ref 542494(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 747).
Ref 528452J Med Chem. 2006 Oct 5;49(20):5947-57.Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists.
Ref 531214Bioorg Med Chem. 2010 Nov 15;18(22):7809-15. Epub 2010 Sep 29.1-Bromo-3-(1',1'-dimethylalkyl)-1-deoxy-|?(8)-tetrahydrocannabinols: New selective ligands for the cannabinoid CB(2) receptor.

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