Drug General Information
Drug ID
D02UID
Former ID
DNC008994
Drug Name
WAY-252623
Drug Type
Small molecular drug
Indication Atherosclerosis [ICD9: 414.0, 440; ICD10:I70] Investigative [529781]
Structure
Download
2D MOL

3D MOL

Formula
C21H12ClF5N2
Canonical SMILES
C1=CC2=C(N(N=C2C(=C1)C(F)(F)F)CC3=C(C=C(C=C3)F)Cl)C4=CC<br />=C(C=C4)F
InChI
1S/C21H12ClF5N2/c22-18-10-15(24)9-6-13(18)11-29-20(12-4-7-14(23)8-5-12)16-2-1-3-17(19(16)28-29)21(25,26)27/h1-10H,11H2
InChIKey
KYWWJENKIMRJBI-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Oxysterols receptor LXR-alpha Target Info Inhibitor [529781]
Pregnane X receptor Target Info Inhibitor [529781]
mRNA of androgen receptor Target Info Inhibitor [529781]
mRNA of glucocorticoid receptor Target Info Inhibitor [529781]
Oxysterols receptor LXR-beta Target Info Inhibitor [529781]
KEGG Pathway PPAR signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis Chsa04114:Oocyte meiosis
Pathways in cancer
Prostate cancerhsa04080:Neuroactive ligand-receptor interaction
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling PathwayNetPath_14:IL2 Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptorsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY networksmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
FOXA2 and FOXA3 transcription factor networks
Glucocorticoid receptor regulatory network
AP-1 transcription factor networkrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
Reactome Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3R-HSA-1368108:BMAL1:CLOCK,NPAS2 activates circadian gene expressionR-HSA-383280:Nuclear Receptor transcription pathway
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Liver X Receptor Pathway
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Nuclear ReceptorsWP299:Nuclear Receptors in Lipid Metabolism and Toxicity
Pregnane X Receptor pathway
Drug Induction of Bile Acid Pathway
Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathwayWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
SIDS Susceptibility Pathways
Endoderm Differentiation
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Circadian Clock
Nuclear ReceptorsWP1982:SREBP signalling
References
Ref 529781J Med Chem. 2008 Nov 27;51(22):7161-8.Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis.
Ref 529781J Med Chem. 2008 Nov 27;51(22):7161-8.Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis.

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