Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02QCD
|
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| Former ID |
DNC013272
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| Drug Name |
DEXMETHYLPHENIDATE HYDROCHLORIDE
|
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| Drug Type |
Small molecular drug
|
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| Indication | Attention deficit hyperactivity disorder [ICD9: 314; ICD10:F90] | Approved | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C14H20ClNO2
|
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| Canonical SMILES |
COC(=O)C(C1CCCCN1)C2=CC=CC=C2.Cl
|
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| InChI |
1S/C14H19NO2.ClH/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12;/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3;1H/t12-,13-;/m1./s1
|
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| InChIKey |
JUMYIBMBTDDLNG-OJERSXHUSA-N
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| PubChem Compound ID | |||||
| SuperDrug ATC ID |
N06BA11
|
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| Target and Pathway | |||||
| Target(s) | Sodium-dependent dopamine transporter | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Dopaminergic synapse | ||||
| Parkinson's disease | |||||
| Cocaine addiction | |||||
| Amphetamine addiction | |||||
| Alcoholism | |||||
| PANTHER Pathway | Adrenaline and noradrenaline biosynthesis | ||||
| Parkinson disease | |||||
| Dopamine receptor mediated signaling pathway | |||||
| Pathway Interaction Database | Alpha-synuclein signaling | ||||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | ||||
| WikiPathways | Monoamine Transport | ||||
| NRF2 pathway | |||||
| Dopaminergic Neurogenesis | |||||
| Parkinsons Disease Pathway | |||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | |||||
| Neurotransmitter Clearance In The Synaptic Cleft | |||||
| References | |||||
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
| REF 2 | J Med Chem. 2007 May 31;50(11):2718-31. Epub 2007 May 10.Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. | ||||
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