Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02ICX
|
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| Former ID |
DNC006218
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| Drug Name |
PYROVALERONE
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [530137] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C16H24ClNO
|
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| Canonical SMILES |
CCCC(C(=O)C1=CC=C(C=C1)C)N2CCCC2
|
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| InChI |
1S/C16H23NO/c1-3-6-15(17-11-4-5-12-17)16(18)14-9-7-13(2)8-10-14/h7-10,15H,3-6,11-12H2,1-2H3
|
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| InChIKey |
SWUVZKWCOBGPTH-UHFFFAOYSA-N
|
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| CAS Number |
CAS 3563-49-3
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Sodium-dependent noradrenaline transporter | Target Info | Inhibitor | [528036] | |
| Sodium-dependent dopamine transporter | Target Info | Inhibitor | [530137] | ||
| Sodium-dependent serotonin transporter | Target Info | Inhibitor | [528036] | ||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Adrenaline and noradrenaline biosynthesisP00001:Adrenaline and noradrenaline biosynthesis | ||||
| Parkinson disease | |||||
| Dopamine receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway | |||||
| 5HT2 type receptor mediated signaling pathway | |||||
| 5HT3 type receptor mediated signaling pathway | |||||
| 5HT4 type receptor mediated signaling pathway | |||||
| Pathway Interaction Database | Alpha-synuclein signaling | ||||
| WikiPathways | Monoamine Transport | ||||
| NRF2 pathway | |||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport | |||||
| Dopaminergic Neurogenesis | |||||
| Parkinsons Disease Pathway | |||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | |||||
| Neurotransmitter Clearance In The Synaptic CleftWP727:Monoamine Transport | |||||
| SIDS Susceptibility Pathways | |||||
| Synaptic Vesicle Pathway | |||||
| Serotonin Transporter Activity | |||||
| References | |||||
| Ref 528036 | J Med Chem. 2006 Feb 23;49(4):1420-32.1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. | ||||
| Ref 530137 | Bioorg Med Chem. 2009 Jun 1;17(11):3770-4. Epub 2009 May 3.A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone. | ||||
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