| Drug General Information |
| Drug ID |
D02ICX
|
| Former ID |
DNC006218
|
| Drug Name |
PYROVALERONE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H24ClNO
|
| Canonical SMILES |
CCCC(C(=O)C1=CC=C(C=C1)C)N2CCCC2
|
| InChI |
1S/C16H23NO/c1-3-6-15(17-11-4-5-12-17)16(18)14-9-7-13(2)8-10-14/h7-10,15H,3-6,11-12H2,1-2H3
|
| InChIKey |
SWUVZKWCOBGPTH-UHFFFAOYSA-N
|
| CAS Number |
CAS 3563-49-3
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Sodium-dependent noradrenaline transporter |
Target Info |
Inhibitor |
[2]
|
|---|
| Sodium-dependent dopamine transporter |
Target Info |
Inhibitor |
[1]
|
| Sodium-dependent serotonin transporter |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
Dopaminergic synapse
|
|
Parkinson's disease
|
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Cocaine addiction
|
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Amphetamine addiction
|
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Alcoholismhsa04726:Serotonergic synapse
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Adrenaline and noradrenaline biosynthesisP00001:Adrenaline and noradrenaline biosynthesis
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Parkinson disease
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Dopamine receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
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5HT2 type receptor mediated signaling pathway
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5HT3 type receptor mediated signaling pathway
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5HT4 type receptor mediated signaling pathway
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Pathway Interaction Database
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Alpha-synuclein signaling
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|
Reactome
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Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
|
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WikiPathways
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Monoamine Transport
|
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NRF2 pathway
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Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
|
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Dopaminergic Neurogenesis
|
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Parkinsons Disease Pathway
|
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Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
|
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Neurotransmitter Clearance In The Synaptic CleftWP727:Monoamine Transport
|
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SIDS Susceptibility Pathways
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Synaptic Vesicle Pathway
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Serotonin Transporter Activity
|
| References |
| REF 1 | Bioorg Med Chem. 2009 Jun 1;17(11):3770-4. Epub 2009 May 3.A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone. |
|---|
| REF 2 | J Med Chem. 2006 Feb 23;49(4):1420-32.1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. |
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