Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02GJZ
|
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| Former ID |
DNAP001686
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| Drug Name |
Ioflupane i-123
|
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| Synonyms |
Datscan (TN)
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| Drug Type |
Small molecular drug
|
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| Indication | Parkinson's disease [ICD9: 332; ICD10:G20] | Approved | [1] | ||
| Company |
GE Healthcare
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C18H23FINO2
|
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| Canonical SMILES |
COC(=O)C1C2CCC(N2CCCF)CC1C3=CC=C(C=C3)I
|
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| InChI |
1S/C18H23FINO2/c1-23-18(22)17-15(12-3-5-13(20)6-4-12)11-14-7-8-16(17)21(14)10-2-9-19/h3-6,14-17H,2,7-11H2,1H3/t14?,15-,16?,17+/m1/s1/i20-4
|
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| InChIKey |
HXWLAJVUJSVENX-PUMJCJFRSA-N
|
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| CAS Number |
CAS 155798-07-5
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| ChEBI ID |
ChEBI:68855
|
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| SuperDrug ATC ID |
V09AB03
|
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| Target and Pathway | |||||
| Target(s) | Sodium-dependent dopamine transporter | Target Info | Modulator | [2] | |
| KEGG Pathway | Dopaminergic synapse | ||||
| Parkinson's disease | |||||
| Cocaine addiction | |||||
| Amphetamine addiction | |||||
| Alcoholism | |||||
| PANTHER Pathway | Adrenaline and noradrenaline biosynthesis | ||||
| Parkinson disease | |||||
| Dopamine receptor mediated signaling pathway | |||||
| Pathway Interaction Database | Alpha-synuclein signaling | ||||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | ||||
| WikiPathways | Monoamine Transport | ||||
| NRF2 pathway | |||||
| Dopaminergic Neurogenesis | |||||
| Parkinsons Disease Pathway | |||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | |||||
| Neurotransmitter Clearance In The Synaptic Cleft | |||||
| References | |||||
| REF 1 | 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4. | ||||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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