Drug Information
Drug General Information | |||||
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Drug ID |
D02CNL
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Former ID |
DIB018285
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Drug Name |
[3H]epibatidine
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [540594] | ||
Formula |
C11H13ClN2
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InChI |
InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2
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InChIKey |
NLPRAJRHRHZCQQ-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Neuronal acetylcholinereceptor subunit alpha-2 | Target Info | Agonist | [543841] | |
Neuronal acetylcholine receptor protein, beta-2 chain | Target Info | Agonist | [543842] | ||
Acetylcholine receptor | Target Info | Agonist | [543844] | ||
nicotinic acetylcholine receptor alpha8 subunit (avian) | Target Info | Modulator | [543958] | ||
Neuronal acetylcholine receptor protein, alpha-7 chain | Target Info | Agonist | [543845] | ||
KEGG Pathway | Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction | ||||
Cholinergic synapse | |||||
Nicotine addictionhsa04080:Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway | |||||
Neuroactive ligand-receptor interaction | |||||
Nicotine addiction | |||||
Chemical carcinogenesis | |||||
Reactome | Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | ||||
Highly calcium permeable nicotinic acetylcholine receptorsR-HSA-629587:Highly sodium permeable acetylcholine nicotinic receptors | |||||
Highly calcium permeable nicotinic acetylcholine receptorsR-HSA-390648:Muscarinic acetylcholine receptors | |||||
Acetylcholine regulates insulin secretion | |||||
Highly sodium permeable acetylcholine nicotinic receptors | |||||
Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsR-HSA-629594:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | |||||
WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellWP706:SIDS Susceptibility Pathways | ||||
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
Nicotine Activity on Dopaminergic NeuronsWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellWP706:SIDS Susceptibility Pathways | |||||
References | |||||
Ref 543841 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 463). | ||||
Ref 543842 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 465). | ||||
Ref 543844 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 467). | ||||
Ref 543845 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 468). | ||||
Ref 543958 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 752). |
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