| Drug General Information |
| Drug ID |
D01ZEY
|
| Former ID |
DIB011054
|
| Drug Name |
MDL-201112
|
| Synonyms |
Carbocyclic nucleoside, Hoechst; MDL-201449; MDL-201449A
|
| Drug Type |
Small molecular drug
|
| Indication |
Colitis [ICD9: 556.9; ICD10:K50-K52]
|
Terminated |
[1]
|
|---|
| Company |
Hoechst Marion Roussel Inc
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C10H13N5O
|
| Canonical SMILES |
n1(c2c(nc1)c(ncn2)N)[C@H]1C[C@@H](CC1)O
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Tumor necrosis factor |
Target Info |
Inhibitor |
[2]
|
|---|
|
KEGG Pathway
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MAPK signaling pathway
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Cytokine-cytokine receptor interaction
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NF-kappa B signaling pathway
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Sphingolipid signaling pathway
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mTOR signaling pathway
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Apoptosis
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TGF-beta signaling pathway
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Osteoclast differentiation
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Antigen processing and presentation
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Toll-like receptor signaling pathway
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NOD-like receptor signaling pathway
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RIG-I-like receptor signaling pathway
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Hematopoietic cell lineage
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Natural killer cell mediated cytotoxicity
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T cell receptor signaling pathway
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Fc epsilon RI signaling pathway
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TNF signaling pathway
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Adipocytokine signaling pathway
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Type II diabetes mellitus
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Non-alcoholic fatty liver disease (NAFLD)
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Type I diabetes mellitus
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Alzheimer's disease
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Amyotrophic lateral sclerosis (ALS)
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Pertussis
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Legionellosis
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Leishmaniasis
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Chagas disease (American trypanosomiasis)
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African trypanosomiasis
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Malaria
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Toxoplasmosis
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Amoebiasis
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Tuberculosis
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Hepatitis C
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Hepatitis B
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Influenza A
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HTLV-I infection
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Herpes simplex infection
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Proteoglycans in cancer
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Asthma
|
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Inflammatory bowel disease (IBD)
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Systemic lupus erythematosus
|
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Rheumatoid arthritis
|
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Allograft rejection
|
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Graft-versus-host disease
|
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Hypertrophic cardiomyopathy (HCM)
|
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Dilated cardiomyopathy
|
|
NetPath Pathway
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TCR Signaling Pathway
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IL2 Signaling Pathway
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IL3 Signaling Pathway
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IL4 Signaling Pathway
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Leptin Signaling Pathway
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RANKL Signaling Pathway
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IL1 Signaling Pathway
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PANTHER Pathway
|
Apoptosis signaling pathway
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Wnt signaling pathway
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Pathway Interaction Database
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IL27-mediated signaling events
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Canonical NF-kappaB pathway
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
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Angiopoietin receptor Tie2-mediated signaling
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Signaling events mediated by HDAC Class I
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TNF receptor signaling pathway
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Ceramide signaling pathway
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amb2 Integrin signaling
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RXR and RAR heterodimerization with other nuclear receptor
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IL23-mediated signaling events
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HIV-1 Nef: Negative effector of Fas and TNF-alpha
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Caspase Cascade in Apoptosis
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Cellular roles of Anthrax toxin
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Downstream signaling in naï
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PathWhiz Pathway
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Fc Epsilon Receptor I Signaling in Mast Cells
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Reactome
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Transcriptional regulation of white adipocyte differentiation
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TNFR1-induced proapoptotic signaling
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Regulation of TNFR1 signaling
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TNFR1-induced NFkappaB signaling pathway
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TNFR1-mediated ceramide production
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TNFR2 non-canonical NF-kB pathway
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TNF signaling
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WikiPathways
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Toll-like receptor signaling pathway
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Monoamine Transport
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SIDS Susceptibility Pathways
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TGF Beta Signaling Pathway
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Cytokines and Inflammatory Response
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MAPK Signaling Pathway
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EV release from cardiac cells and their functional effects
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FAS pathway and Stress induction of HSP regulation
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Apoptosis-related network due to altered Notch3 in ovarian cancer
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Cardiac Hypertrophic Response
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Transcriptional Regulation of White Adipocyte Differentiation
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Aryl Hydrocarbon Receptor
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Apoptosis
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Nanoparticle triggered regulated necrosis
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Amyotrophic lateral sclerosis (ALS)
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Adipogenesis
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Allograft Rejection
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TNF alpha Signaling Pathway
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TWEAK Signaling Pathway
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Extrinsic Pathway for Apoptosis
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Folate Metabolism
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MicroRNAs in cardiomyocyte hypertrophy
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Vitamin B12 Metabolism
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Selenium Micronutrient Network
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Regulation of toll-like receptor signaling pathway
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Matrix Metalloproteinases
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| References |
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007330) |
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| REF 2 | Effect of the carbocyclic nucleoside analogue MDL 201,112 on inhibition of interferon-gamma-induced priming of Lewis (LEW/N) rat macrophages for enhanced respiratory burst and MHC class II Ia+ antigen expression. J Leukoc Biol. 1994 Aug;56(2):133-44. |
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