| Drug General Information |
| Drug ID |
D01ZCR
|
| Former ID |
DIB018269
|
| Drug Name |
[3H]darifenacin
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C28H30N2O2
|
| InChI |
InChI=1S/C28H30N2O2/c29-27(31)28(23-7-3-1-4-8-23,24-9-5-2-6-10-24)25-14-17-30(20-25)16-13-21-11-12-26-22(19-21)15-18-32-26/h1-12,19,25H,13-18,20H2,(H2,29,31)/t25-/m1/s1
|
| InChIKey |
HXGBXQDTNZMWGS-RUZDIDTESA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
7979027, 10944518, 14856314, 17397751, 36887144, 46508104, 50070895, 50113277, 50275204, 81145912, 85083117, 85583237, 92719451, 103435149, 104004586, 104631174, 126620787, 126651550, 128126220, 134338376, 135030473, 135650160, 135651146, 136947991, 137004287, 142807983, 144240344, 152047381, 160963842, 163621141, 163686486, 164826587, 175268333, 179149827, 186007015, 196107254, 223541474, 223831811, 226439188, 241032006, 249858507, 251916719, 251917958, 252215250
|
| Target and Pathway |
| Target(s) |
Muscarinic acetylcholine receptor M3 |
Target Info |
Antagonist |
[2]
|
|---|
| Muscarinic receptor |
Target Info |
Antagonist |
[2]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Cholinergic synapse
|
|
Regulation of actin cytoskeleton
|
|
Insulin secretion
|
|
Salivary secretion
|
|
Gastric acid secretion
|
|
Pancreatic secretionhsa04020:Calcium signaling pathway
|
|
cAMP signaling pathway
|
|
PI3K-Akt signaling pathway
|
|
PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
|
PathWhiz Pathway
|
Gastric Acid ProductionPW000564:Muscle/Heart Contraction
|
|
Reactome
|
Muscarinic acetylcholine receptors
|
|
Acetylcholine regulates insulin secretion
|
|
G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
|
|
G alpha (q) signalling events
|
|
WikiPathways
|
Monoamine GPCRs
|
|
Calcium Regulation in the Cardiac Cell
|
|
Regulation of Actin Cytoskeleton
|
|
GPCRs, Class A Rhodopsin-like
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
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Integration of energy metabolism
|
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GPCR ligand binding
|
|
GPCR downstream signaling
|
|
GPCRs, OtherWP58:Monoamine GPCRs
|
|
Secretion of Hydrochloric Acid in Parietal Cells
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 319). |
|---|
| REF 2 | Characterisation of [3H]-darifenacin as a novel radioligand for the study of muscarinic M3 receptors. J Recept Signal Transduct Res. 1997 Jan-May;17(1-3):177-84. |
|---|
