Drug Information

Drug General Information
Drug ID
D01RWY
Former ID
DNC010126
Drug Name
2-(N-tert-Butylamino)-3'-chloroheptanophenone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530442]
Structure
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2D MOL

3D MOL
Formula
C17H26ClNO
Canonical SMILES
CCCCCC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C
InChI
1S/C17H26ClNO/c1-5-6-7-11-15(19-17(2,3)4)16(20)13-9-8-10-14(18)12-13/h8-10,12,15,19H,5-7,11H2,1-4H3
InChIKey
OROOSQVGDDDAFY-UHFFFAOYSA-N
PubChem Compound ID
44542656
Target and Pathway
Target(s) Sodium-dependent dopamine transporter Target Info Inhibitor [530442]
Sodium-dependent noradrenaline transporter Target Info Inhibitor [530442]
KEGG Pathway Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Pathway Interaction Database Alpha-synuclein signaling
Reactome Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic CleftWP727:Monoamine Transport
References
Ref 530442J Med Chem. 2009 Nov 12;52(21):6768-81.Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction.
Ref 530442J Med Chem. 2009 Nov 12;52(21):6768-81.Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction.

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