Drug Information

Drug General Information
Drug ID
D01PZU
Former ID
DNC007991
Drug Name
N-ethyl-5,6-dip-tolylpyrazine-2-carboxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528851]
Structure
Download
2D MOL

3D MOL
Formula
C21H21N3O
Canonical SMILES
CCNC(=O)C1=CN=C(C(=N1)C2=CC=C(C=C2)C)C3=CC=C(C=C3)C
InChI
1S/C21H21N3O/c1-4-22-21(25)18-13-23-19(16-9-5-14(2)6-10-16)20(24-18)17-11-7-15(3)8-12-17/h5-13H,4H2,1-3H3,(H,22,25)
InChIKey
BAXIFQMQEGUGGQ-UHFFFAOYSA-N
PubChem Compound ID
44440707
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Inhibitor [528851]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 528851Bioorg Med Chem Lett. 2007 Jul 15;17(14):3978-82. Epub 2007 Apr 29.Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series.
Ref 528851Bioorg Med Chem Lett. 2007 Jul 15;17(14):3978-82. Epub 2007 Apr 29.Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series.

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