| Drug General Information |
| Drug ID |
D01JGV
|
| Former ID |
DNAP001616
|
| Drug Name |
Ajmalicine
|
| Drug Type |
Small molecular drug
|
| Indication |
Circulatory disorders [ICD10:I00-I99]
|
Approved |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C21H24N2O3
|
| Canonical SMILES |
CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45
|
| InChI |
1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3
|
| InChIKey |
GRTOGORTSDXSFK-UHFFFAOYSA-N
|
| CAS Number |
CAS 483-04-5
|
| PubChem Compound ID |
|
| PubChem Substance ID |
114926, 114938, 400025, 3498439, 5381153, 7977315, 8138368, 8138377, 9397932, 10523828, 10589097, 11445844, 11445867, 14900932, 30049750, 49908753, 51071925, 57400548, 58003974, 76413967, 81041172, 85209801, 88961357, 92221568, 93576886, 103828520, 104445554, 105277899, 117551855, 118490164, 118980383, 124659233, 124813117, 125321929, 125351251, 126424550, 126448986, 126469248, 127996783, 135894816, 137009041, 143725030, 162220009, 164806067, 169959173, 179226193, 217582612, 225209848, 226649216, 242052838
|
| Target and Pathway |
| Target(s) |
Beta-1 adrenergic receptor |
Target Info |
Modulator |
[2]
|
|---|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
cGMP-PKG signaling pathway
|
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cAMP signaling pathway
|
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Neuroactive ligand-receptor interaction
|
|
Endocytosis
|
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Adrenergic signaling in cardiomyocytes
|
|
Gap junction
|
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Salivary secretion
|
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Dilated cardiomyopathy
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Beta1 adrenergic receptor signaling pathway
|
|
PathWhiz Pathway
|
Muscle/Heart Contraction
|
|
Reactome
|
Adrenoceptors
|
|
G alpha (s) signalling events
|
|
WikiPathways
|
Monoamine GPCRs
|
|
Calcium Regulation in the Cardiac Cell
|
|
GPCRs, Class A Rhodopsin-like
|
|
Endothelin Pathways
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|
GPCR ligand binding
|
|
GPCR downstream signaling
|
| References |
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 |
|---|
| REF 2 | Medicinal plants in therapy. Bull World Health Organ. 1985;63(6):965-81. |
|---|
