| Drug General Information |
| Drug ID |
D01ABR
|
| Former ID |
DNC006822
|
| Drug Name |
1-(1-phenyl-2-(2-propoxyphenyl)ethyl)piperazine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C21H28N2O
|
| Canonical SMILES |
CCCOC1=CC=CC=C1CC(C2=CC=CC=C2)N3CCNCC3
|
| InChI |
1S/C21H28N2O/c1-2-16-24-21-11-7-6-10-19(21)17-20(18-8-4-3-5-9-18)23-14-12-22-13-15-23/h3-11,20,22H,2,12-17H2,1H3
|
| InChIKey |
PSIGDYKJTYBHDY-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Sodium-dependent noradrenaline transporter |
Target Info |
Inhibitor |
[1]
|
|---|
| Potassium voltage-gated channel subfamily H member 2 |
Target Info |
Inhibitor |
[1]
|
| Sodium-dependent dopamine transporter |
Target Info |
Inhibitor |
[1]
|
| Sodium-dependent serotonin transporter |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Dopaminergic synapse
|
|
Parkinson's disease
|
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Cocaine addiction
|
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Amphetamine addiction
|
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Alcoholismhsa04726:Serotonergic synapse
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Adrenaline and noradrenaline biosynthesisP00001:Adrenaline and noradrenaline biosynthesis
|
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Parkinson disease
|
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Dopamine receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
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5HT2 type receptor mediated signaling pathway
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5HT3 type receptor mediated signaling pathway
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5HT4 type receptor mediated signaling pathway
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Pathway Interaction Database
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Alpha-synuclein signaling
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PathWhiz Pathway
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Muscle/Heart Contraction
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Reactome
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Na+/Cl- dependent neurotransmitter transportersR-HSA-1296072:Voltage gated Potassium channelsR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
|
|
WikiPathways
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Monoamine Transport
|
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NRF2 pathway
|
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Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP706:SIDS Susceptibility Pathways
|
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Hematopoietic Stem Cell Differentiation
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Potassium ChannelsWP727:Monoamine Transport
|
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Dopaminergic Neurogenesis
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Parkinsons Disease Pathway
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Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
|
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Neurotransmitter Clearance In The Synaptic CleftWP727:Monoamine Transport
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SIDS Susceptibility Pathways
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Synaptic Vesicle Pathway
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Serotonin Transporter Activity
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. Epub 2010 Apr 18.Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reducing ion channel activity. |
|---|
