Drug Information

Drug General Information
Drug ID
D00SLY
Former ID
DNCL003608
Drug Name
Umeclidinium
Synonyms
573719
Drug Type
Small molecular drug
Indication Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Approved [542375], [550101]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C29H34NO2+
InChI
InChI=1S/C29H34NO2/c31-29(26-12-6-2-7-13-26,27-14-8-3-9-15-27)28-16-19-30(20-17-28,21-18-28)22-23-32-24-25-10-4-1-5-11-25/h1-15,31H,16-24H2/q+1
InChIKey
FVTWTVQXNAJTQP-UHFFFAOYSA-N
PubChem Compound ID
11519070
PubChem Substance ID
78645667, 104114420, 135268598, 135626898, 137574739, 160687806, 178103926, 198977602, 223444256, 228187522, 245802352, 247480304
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M5 Target Info Modulator [542375]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 542375(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7354).
Ref 550101Clinical pipeline report, company report or official report of GlaxoSmithKline.
Ref 542375(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7354).

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